BACKGROUND:A variety of definitions of evidence-based practice (EBP) exist. However, definitions are in themselves insufficient to explain the underlying processes of EBP and to differentiate between an evidence-based process and evidence-based outcome. There is a need for a clear statement…

BACKGROUND:Primary prevention of breast cancer through prophylactic mastectomy can reduce the risk of malignancy in high-risk individuals. No type of mastectomy completely removes all breast tissue, but a subcutaneous mastectomy leaves more tissue in situ than does a simple mastectomy.CASE…

This article explores commercial, academic, and national initiatives aimed at usingsequencing technologies to generate “actionable” genomic results that can beapplied to the clinical management of oncology patients. We argue that the term“actionable” is not merely a buzzword, but signals the…

Researchers and clinicians in the field of oncology have now entered the second decadeof targeted therapy, widely held to be a revolutionary new form of cancer therapyresearch. The present era is regarded as the end of brute empiricism: as laboratoryresearchers…

This article traces the history of research on resistance to drug therapy in oncology using scientometric techniques and qualitative analysis. Using co-citation analysis, we generate maps to visualize subdomains in resistance research in two time periods, 1975–1990 and 1995–2010. These…

Increasingly, knowledge-based tasks such as new product development and market research are being conducted by geographically dispersed teams. Early evidence from knowledge-based view of the firm and geographically dispersed work literatures suggests that at least four kinds of knowledge gaps---transactive…

Knowledge-based Cascade-correlation is a neural network algorithm that combines inductive learning and knowledge transfer (Shultz & Rivest, 2001). In the present thesis, this algorithm is tested on several real-world and artificial problems, and extended in several ways. The first extension…

In order to close the gap that exists between the research areas of mathematics anxiety and mathematics learning, this study examined cognitive, metacognitive, and affective aspects of mathematics anxiety as well as students' mathematics performance and competence. One hundred and…

Research on self-regulated learning (SRL) in hypermedia-learning environments is a growing area of interest. One major issue is the role of prior knowledge, which can influence how students interact with hypermedia-learning systems in terms of their use of SRL strategies.…

Efforts to resolve environmental planning and decision-making conflicts usually focus on participant involvement, mutual understanding of the problem situation, evaluation criteria identification, data availability, and potential alternative solutions. However, as the alternatives become less distinct and participant values more diverse,…