| Título: | 21st Century Oncology: A Tangled Web |
| Autores: |
Cambrosio, Alberto Keating, Peter |
| Fecha: |
2013 June 2014 |
| Publicador: | McGill University - MCGILL |
| Fuente: |
 |
| Tipo: | Postprint |
| Tema: |
Medicine -- Periodicals. Médecine -- Périodiques. |
| Descripción: | Researchers and clinicians in the field of oncology have now entered the second decadeof targeted therapy, widely held to be a revolutionary new form of cancer therapyresearch. The present era is regarded as the end of brute empiricism: as laboratoryresearchers slowly unravel the mechanisms of oncogenes and their protein products, andas small molecules and antibodies target specific cell-surface and intracellular receptors,therapeutic research is now seen as a direct application of laboratory knowledge in theclinic. The poster child for this revolution has been the astonishing success ofimatinibtyrosine kinase (TK), in chronic myelogenous leukemia (CML). In this essay werevisit the imatinib story to show that, despite substantial progress in the understanding ofcancer, therapeutic research more closely resembles a tangled web than a deductive chainleading from the laboratory to the clinic.[...] |
| Idioma: | eng |
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