| Título: | On Being ‘Actionable’: Clinical Sequencing and the Emerging Contours of a Regime of Genomic Medicine in Oncology. |
| Autores: |
Cambrosio, Alberto Nelson, Nicole Keating, Peter |
| Fecha: |
2013 June 2014 |
| Publicador: | McGill University - MCGILL |
| Fuente: |
 |
| Tipo: | Postprint |
| Tema: |
Genetic engineering -- Social aspects -- Periodicals. Biotechnology -- Social aspects -- Periodicals. Genetics -- Periodicals. Social Change -- Periodicals. |
| Descripción: | This article explores commercial, academic, and national initiatives aimed at usingsequencing technologies to generate “actionable” genomic results that can beapplied to the clinical management of oncology patients. We argue that the term“actionable” is not merely a buzzword, but signals the emergence of a distinctivesociotechnical regime of genomic medicine in oncology. Unlike other regimes ofgenomic medicine that are organized around assessing and managing inherited riskfor developing cancer (e.g., BRCA testing), actionable regimes aim to generatepredictive relationships between genetic information and drug therapies, therebygenerating new kinds of clinical actions. We explore how these genomic results aremade actionable by articulating them with existing clinical routines, clinical trials,regulatory regimes, and health care systems; and in turn, how clinical sequencingprograms have begun to reconfigure knowledge and practices in oncology.Actionability regimes confirm the emergence of bio-clinical decision-making inoncology, whereby the articulation of molecular hypotheses and experimentaltherapeutics become central to patient care. |
| Idioma: | eng |
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