Knowledge on the biosynthetic pathways of the monoter­pene alkaloids is enormous, but little is known about their mechanism of transporting system from the plant cell. There is not concrete evi­dence confirming the role of ABC transporters in the secretion of monoterpene indole alkaloids (MIAs) in Catharanthus roseus. There­fore, in order to determine the role of different transporting systemsinvolved in the MIAs translocation, we employed…

The question of rationality and modernity has played a key role in defining the West’sunderstanding of itself in relation to “the other.” Much of this self-defining was done in a waythat privileged a western model of rationality, which itself was…

This article explores commercial, academic, and national initiatives aimed at usingsequencing technologies to generate “actionable” genomic results that can beapplied to the clinical management of oncology patients. We argue that the term“actionable” is not merely a buzzword, but signals the…

Researchers and clinicians in the field of oncology have now entered the second decadeof targeted therapy, widely held to be a revolutionary new form of cancer therapyresearch. The present era is regarded as the end of brute empiricism: as laboratoryresearchers…

BACKGROUND:Primary prevention of breast cancer through prophylactic mastectomy can reduce the risk of malignancy in high-risk individuals. No type of mastectomy completely removes all breast tissue, but a subcutaneous mastectomy leaves more tissue in situ than does a simple mastectomy.CASE…

I consider the implementation problem under complete information and employ Nash equilibrium as a solution concept. A socially desirable rule is given as a correspondence from the set of states to the set of outcomes. This social choice rule is…

Saltwater Chronicles investigates the notion of “islandness” in contemporary Newfoundland readership through two in-depth case studies of book clubs as representational spaces in the elaboration of local knowledge and identities. We demonstrate how select Newfoundland readers perform acts of regeneration…

Detailed knowledge of the tip apex structure is necessary for quantitative comparison between theory-based simulations and experimental observations of tip-substrate interactions in scanning probe microscopy (SPM). Here, we discuss field ion microscopy (FIM) techniques to characterize and atomically define SPM…

One does not have to be a fierce advocate of dialectics to consider the claim that the exercise of dystopic imagination may represent a necessary stage to think a better world. If it is good to know the worst, that does not…

One does not have to be a fierce advocate of dialectics to consider the claim that the exercise of dystopic imagination may represent a necessary stage to think a better world. If it is good to know the worst, that does not…