This article explores commercial, academic, and national initiatives aimed at usingsequencing technologies to generate “actionable” genomic results that can beapplied to the clinical management of oncology patients. We argue that the term“actionable” is not merely a buzzword, but signals the…

Researchers and clinicians in the field of oncology have now entered the second decadeof targeted therapy, widely held to be a revolutionary new form of cancer therapyresearch. The present era is regarded as the end of brute empiricism: as laboratoryresearchers…

This article traces the history of research on resistance to drug therapy in oncology using scientometric techniques and qualitative analysis. Using co-citation analysis, we generate maps to visualize subdomains in resistance research in two time periods, 1975–1990 and 1995–2010. These…

In contemporary organizations, it is common to encounter teams that are formed to create novel outcomes and that are supported by Information Communication Technologies (ICT). These knowledge teams are also formed by members with diverse expertise, in order to create…

This thesis examines the transmission of intergenerational cultural knowledge on eastern James Bay Cree lands. Geospatial technologies and the representation of Cree knowledge are explored, with emphasis on the geoweb. A geoweb with two parts, old and new, is theorized…

Reference documentation is an important source of information on API usage. Programmers, however, can easily overlook reference information because of its tedious nature, and because the information they seek can be buried among irrelevant or boiler-plate text. We propose to…

A significant gap exists between evidence-based practice (EBP) and actual occupational therapy (OT) practice in the management of a disabling post-stroke impairment - unilateral spatial neglect (USN). With improved patient outcomes linked to the use of best practices, it is…

Knowledge translation (KT) has been referred to as "the methods for closing the gaps from knowledge to practice" (Straus, Tetroe & Graham, 2009). During the 2010-2011 academic year, a research project was conducted in the three high schools of the…

This thesis examines the production and mobilization of Inuit knowledge in and beyond the Canadian Arctic in the context of climate change. Drawing on multi-scale, ethnographic research, it focuses in particular on the role of institutions, such as government departments…

This thesis examines variation in the practices of al-Qaeda and the American counterterrorism community. It posits that the interaction of two permissive factors, background knowledge and relational structure, goes a long way in explaining shifts in the practices of both…