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Recurso libre

Announcing Computational and Structural Biotechnology Journal: not just another open-access journal
Panagiotou, Gianni; Technical University of Denmark

Formato:	info:eu-repo/semantics/article, info:eu-repo/semantics/publishedVersion, Editorial
Enlaces:	Descripción completa.
Fecha:	2012-02-10
Recurso:	Computacional and structural biotechnology journal

Recurso libre

Lipase improvement: goals and strategies
Bassegoda, Arnau; Department of Microbiology. University of Barcelona. Spain - Cesarini, Silvia; Department of Microbiology. University of Barcelona. Spain - Diaz, Pilar; Department of Microbiology. University of Barcelona. Spain

Formato:	info:eu-repo/semantics/article, info:eu-repo/semantics/publishedVersion, Peer-reviewed Article
Enlaces:	-
Fecha:	2012-10-15
Recurso:	Computacional and structural biotechnology journal

Recurso libre

Computational Enzyme Design: Advances, hurdles and possible ways forward
Linder, Mats; KTH Royal Institute of Technology

Formato:	info:eu-repo/semantics/article, info:eu-repo/semantics/publishedVersion, Peer-reviewed Article
Enlaces:	This mini review addresses recent developments in computational enzyme design. Successful protocols as well as known issues and limitations are discussed from an energetic perspective. It will be argued that improved results can be obtained by including a dynamic treatment…
Fecha:	2012-10-23
Recurso:	Computacional and structural biotechnology journal

Recurso libre

Structural and mechanistic fundamentals for designing of cellulases
Marana, Sandro Roberto; Instituto de Química - USP Departamento de Bioquímica

Formato:	info:eu-repo/semantics/article, info:eu-repo/semantics/publishedVersion, Peer-reviewed Article
Enlaces:	-
Fecha:	2012-10-16
Recurso:	Computacional and structural biotechnology journal

Recurso libre

Computer-Aided Protein Directed Evolution: a Review of Web Servers, Databases and other Computational Tools for Protein Engineering
Verma, Rajni; Jacobs University Bremen - Schwaneberg, Ulrich; RWTH Aachen University - Roccatano, Danilo; Jacobs University Bremen

Formato:	info:eu-repo/semantics/article, info:eu-repo/semantics/publishedVersion, Peer-reviewed Article
Enlaces:	The combination of computational and directed evolution methods has proven a winning strategy for protein engineering. We refer to this approach as computer-aided protein directed evolution (CAPDE) and the review summarizes the recent developments in this rapidly growing field. We…
Fecha:	2012-10-22
Recurso:	Computacional and structural biotechnology journal

Recurso libre

Rational approaches for engineering carbon-carbon bond forming enzymes
Baker, Perrin - Seah, Stephen; University of Guelph

Formato:	info:eu-repo/semantics/article, info:eu-repo/semantics/publishedVersion, Peer-reviewed Article
Enlaces:	Enzymes that catalyze carbon-carbon bond formation can be exploited as biocatalyst for synthetic organic chemistry. However, natural enzymes frequently do not possess the required properties or specificities to catalyze industrially useful transformations. This mini-review describes recent work using knowledge-guided site-specific…
Fecha:	2012-10-02
Recurso:	Computacional and structural biotechnology journal

Recurso libre

Recent advances in rational approaches for enzyme engineering
Steiner, Kerstin; ACIB GmbH, c/o TU Graz, Petersgasse 14/4, 8010 Graz - Schwab, Helmut; ACIB GmbH, c/o TU Graz, Petersgasse 14/4, 8010 Graz and Institute of Molecular Biotechnology, TU Graz, Petersgasse 14/5, 8010 Graz, Austria

Formato:	info:eu-repo/semantics/article, info:eu-repo/semantics/publishedVersion, Peer-reviewed Article
Enlaces:	Enzymes are an attractive alternative in the asymmetric syntheses of chiral building blocks. To meet the requirements of industrial biotechnology and to introduce new functionalities, the enzymes need to be optimized by protein engineering. This article specifically reviews rational approaches…
Fecha:	2012-10-22
Recurso:	Computacional and structural biotechnology journal

Recurso libre

Metabolic engineering of lactic acid bacteria for the production of industrially important compounds
Papagianni, Maria; Aristotle University of Thessaloniki

Formato:	info:eu-repo/semantics/article, info:eu-repo/semantics/publishedVersion, Peer-reviewed Article
Enlaces:	Lactic acid bacteria (LAB) are receiving increased attention for use as cell factories for the production of metabolites with wide use by the food and pharmaceutical industries. The availability of efficient tools for genetic modification of LAB during the past…
Fecha:	2012-10-29
Recurso:	Computacional and structural biotechnology journal

Recurso libre

Approaches to engineer stability of beetle luciferases
Koksharov, Mikhail; Department of Chemical Enzymology, Faculty of Chemistry, Lomonosov Moscow State University - Ugarova, Natalia; Department of Chemical Enzymology, Faculty of Chemistry, Lomonosov Moscow State University

Formato:	info:eu-repo/semantics/article, info:eu-repo/semantics/publishedVersion, Peer-reviewed Article
Enlaces:	Luciferase enzymes from fireflies and other beetles have many important applications in molecular biology, biotechnology, analytical chemistry and several other areas. Many novel beetle luciferases with promising properties have been reported in the recent years. However, actual and potential applications…
Fecha:	2012-10-09
Recurso:	Computacional and structural biotechnology journal

Recurso libre

10.

Directed evolution: selection of the host organism
Pourmir, Azadeh - Johannes, Tyler W; The University of Tulsa

Formato:	info:eu-repo/semantics/article, info:eu-repo/semantics/publishedVersion, Peer-reviewed Article
Enlaces:	Directed evolution has become a well-established tool for improving proteins and biological systems. A critical aspect of directed evolution is the selection of a suitable host organism for achieving functional expression of the target gene. To date, most directed evolution…
Fecha:	2012-10-27
Recurso:	Computacional and structural biotechnology journal

Recurso libre

11.

Tailor-made biocatalysts: combining thermodynamics, organic synthesis, molecular biology, biochemistry and microbiology for the design of enzyme selections
Jestin, Jean-Luc; Institut Pasteur

Formato:	info:eu-repo/semantics/article, info:eu-repo/semantics/publishedVersion, Peer-reviewed Article
Enlaces:	A general strategy for the isolation of catalysts for given chemical reactions was designed. A first link between genes and their corresponding proteins was established by phage display: using Darwin’s principles on evolution based on selection and amplification, rare protein…
Fecha:	2012-10-28
Recurso:	Computacional and structural biotechnology journal

Recurso libre

12.

The Biochemistry of Vitreoscilla hemoglobin
Stark, Benjamin C.; Illinois Institute of Technology - Dikshit, Kanak L.; Institute of Microbial Technology - Pagilla, Krishna R.; Illinois Institute of Technology

Formato:	info:eu-repo/semantics/article, info:eu-repo/semantics/publishedVersion, Peer-reviewed Article
Enlaces:	The hemoglobin (VHb) from Vitreoscilla was the first bacterial hemoglobin discovered. Its structure and function have been extensively investigated, and engineering of a wide variety of heterologous organisms to express VHb has been performed to increase their growth and productivity. …
Fecha:	2012-10-29
Recurso:	Computacional and structural biotechnology journal

Recurso libre

13.

Progression of 'OMICS' methodologies for understanding the pathogenicity of Corynebacterium pseudotuberculosis: the Brazilian experience
Dorella, Fernanda A; UFMG - Gala-Garcia, Alfonso; UFMG - Pinto, Anne C; UFMG - Sarrouh, Boutros; UFMG - Antunes, Camila A; UFMG - Ribeiro, Dayana; UFMG - Aburjaile, Flávia; UFMG - Fiaux, Karina K; UFMG - Guimarães, Luis C; UFMG - Seyffert, Nubia; UFMG - El-Aouar, Rachid A; UFMG - Silva, Renata; UFMG - Hassan, Syed S; UFMG - Casto, Thiago LP; UFMG - Marques, Wanderson S; UFMG - Ramos, Rommel; UFPA - Carneiro, Adriana; UFPA - de Sá, Pablo; UFPA - Miyoshi, Anderson; UFMG - Azevedo, Vasco; UFMG - Silva, Artur; UFPA

Formato:	info:eu-repo/semantics/article, info:eu-repo/semantics/publishedVersion,
Enlaces:	Since the first successful attempt at sequencing the Corynebacterium pseudotuberculosis genome, large amounts of genomic, transcriptomic and proteomic data have been generated. C. pseudotuberculosis is an interesting bacterium due to its great zoonotic potential and because it causes considerable economic…
Fecha:	2013-10-13
Recurso:	Computacional and structural biotechnology journal

Recurso libre

14.

Probing Genome Maintenance Functions of human RECQ1
Sami, Furqan - Sharma, Sudha

Formato:	info:eu-repo/semantics/article, info:eu-repo/semantics/publishedVersion,
Enlaces:	The RecQ helicases are a highly conserved family of DNA-unwinding enzymes that play key roles in protecting the genome stability in all kingdoms of life. Human RecQ homologs include RECQ1, BLM, WRN, RECQ4, and RECQ5β. Although the individual RecQ-related diseases…
Fecha:	2013-10-18
Recurso:	Computacional and structural biotechnology journal

Recurso libre

15.

Engineering Non-Heme Mono- and Dioxygenases for Biocatalysis
Dror, Adi; Technion - Israel Institute of Technology - Fishman, Ayelet; Technion - Israel Institute of Technology

Formato:	info:eu-repo/semantics/article, info:eu-repo/semantics/publishedVersion, Peer-reviewed Article
Enlaces:	Oxygenases are ubiquitous enzymes that catalyze the introduction of one or two oxygen atoms to unreactive chemical compounds. They require reduction equivalents from NADH or NADPH and comprise metal ions, metal ion complexes, or coenzymes in their active site. Thus,…
Fecha:	2012-10-23
Recurso:	Computacional and structural biotechnology journal

Recurso libre

16.

Metabolic engineering of Corynebacterium glutamicum aimed at alternative carbon sources and new products
Zahoor, Ahmed - Lindner, Steffen Nikolaus - Wendisch, Volker Fritz

Formato:	info:eu-repo/semantics/article, info:eu-repo/semantics/publishedVersion, Peer-reviewed Article
Enlaces:	Corynebacterium glutamicum is well known as the amino acid-producing workhorse of fermentation industry, being used for multi-million-ton scale production of glutamate and lysine for more than 60 years. However, it is only recently that extensive research has focused on engineering…
Fecha:	2012-10-30
Recurso:	Computacional and structural biotechnology journal

Recurso libre

17.

Bioprocess systems engineering: transferring traditional process engineering principles to industrial biotechnology
Koutinas, Michalis; Cyprus University of Technology - Kiparissides, Alexandros; Imperial College London - Pistikopoulos, Efstratios N; Imperial College London - Mantalaris, Athanasios; Imperial College London

Formato:	info:eu-repo/semantics/article, info:eu-repo/semantics/publishedVersion, Peer-reviewed Article
Enlaces:	The complexity of the regulatory network and the interactions that occur in the intracellular environment of microorganisms highlight the importance in developing tractable mechanistic models of cellular functions and systematic approaches for modelling biological systems. To this end, the existing…
Fecha:	2013-03-10
Recurso:	Computacional and structural biotechnology journal

Recurso libre

18.

The Cytotoxic Effects of Low Intensity Visible and Infrared Light on Human Breast Cancer (MCF7) cells
Peidaee, P; Royal Melbourne Institute of Technology - Almansour, N - Shukla, R - Pirogova, E

Formato:	info:eu-repo/semantics/article, info:eu-repo/semantics/publishedVersion,
Enlaces:	A concept of using low intensity light therapy (LILT) as an alternative approach to cancer treatment is at early stages of development; while the therapeutic effects of LILT as a non-invasive treatment modality for localized joint and soft tissue wound…
Fecha:	2013-10-20
Recurso:	Computacional and structural biotechnology journal

Recurso libre

19.

Optimization of enzyme parameters for fermentative production of biorenewable fuels and chemicals
Jarboe, Laura R; Iowa State University - Liu, Ping; Microbiology, Iowa State University - Kautharapu, Kumar Babu; Department of Chemical and Biological Engineering, Iowa State University - Ingram, Lonnie O.; Department of Microbiology and Cell Science, University of Florida

Formato:	info:eu-repo/semantics/article, info:eu-repo/semantics/publishedVersion, Peer-reviewed Article
Enlaces:	Microbial biocatalysts such as Escherichia coli and Saccharomyces cerevisiae have been extensively subjected to Metabolic Engineering for the fermentative production of biorenewable fuels and chemicals. This often entails the introduction of new enzymes, deletion of unwanted enzymes and efforts to…
Fecha:	2012-10-31
Recurso:	Computacional and structural biotechnology journal

Recurso libre

20.

Quantitative HSQC Analyses of Lignin: A Practical Comparison
Sette, Marco; Università degli Studi di Roma 'Tor Vergata' Facoltà di Scienze Matematiche, Fisiche e Naturali Dipartimento di Scienze e Tecnologie Chimiche - Lange, Heiko; Università degli Studi di Roma 'Tor Vergata' Facoltà di Scienze Matematiche, Fisiche e Naturali Dipartimento di Scienze e Tecnologie Chimiche - Crestini, Claudia; Università degli Studi di Roma 'Tor Vergata' Facoltà di Scienze Matematiche, Fisiche e Naturali Dipartimento di Scienze e Tecnologie Chimiche

Formato:	info:eu-repo/semantics/article, info:eu-repo/semantics/publishedVersion,
Enlaces:	Lignin is the second-most abundant polymer after cellulose within the biomass of our planet. Structurally, it displays random oligomeric units without fixed repetition schemes beyond the stage of dimers. Quantitative 1H-13C HSQC measurements have recently greatly facilitated lignin analyses. In…
Fecha:	2013-11-10
Recurso:	Computacional and structural biotechnology journal

Recurso libre

21.

Computational protein design approaches with significant biological outcomes: progress and challenges
Li, Xiaoman; Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences - Zhang, Ziding; China Agricultural University - Song, Jiangning; Monash University; Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences

Formato:	info:eu-repo/semantics/article, info:eu-repo/semantics/publishedVersion, Peer-reviewed Article
Enlaces:	Enzymes are powerful biocatalysts, however, so far there is still a large gap between the number of enzyme-based practical applications and that of naturally occurring enzymes. Multiple experimental approaches have been applied to generate nearly all possible mutations of target…
Fecha:	2012-10-17
Recurso:	Computacional and structural biotechnology journal

Recurso libre

22.

Biochemical and Biophysical Characterization of Recombinant Yeast Proteasome Maturation Factor Ump1
Sá-Moura, Bebiana; IBMC - Instituto de Biologia Molecular e Celular, Universidade do Porto, Rua do Campo Alegre 823, 4150-180 Porto - Simões, Ana Marisa; IBMC - Instituto de Biologia Molecular e Celular, Universidade do Porto, Rua do Campo Alegre 823, 4150-180 Porto - Fraga, Joana; IBMC - Instituto de Biologia Molecular e Celular, Universidade do Porto, Rua do Campo Alegre 823, 4150-180 Porto - Fernandes, Humberto; Centre for Molecular and Structural Biomedicine, CBME/IBB, LA - Abreu, Isabel A.; IBMC - Instituto de Biologia Molecular e Celular, Universidade do Porto, Rua do Campo Alegre 823, 4150-180 Porto - Botelho, Hugo M.; Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa - Gomes, Cláudio M.; Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa - Marques, António J.; Institute for Genetics, University of Cologne, Zülpicher Str. 47, D-50674 Cologne - Dohmen, R. Jürgen; Institute for Genetics, University of Cologne, Zülpicher Str. 47, D-50674 Cologne - Ramos, Paula C.; Centre for Molecular and Structural Biomedicine, CBME/IBB, LA - Macedo-Ribeiro, Sandra; IBMC - Instituto de Biologia Molecular e Celular, Universidade do Porto, Rua do Campo Alegre 823, 4150-180 Porto

Formato:	info:eu-repo/semantics/article, info:eu-repo/semantics/publishedVersion, Peer-reviewed Article
Enlaces:	Protein degradation is essential for maintaining cellular homeostasis. The proteasome is the central enzyme responsible for non-lysosomal protein degradation in eukaryotic cells. Although proteasome assembly is not yet completely understood, a number of cofactors required for proper assembly and maturation…
Fecha:	2013-09-10
Recurso:	Computacional and structural biotechnology journal