| Título: | Recent advances in rational approaches for enzyme engineering |
| Autores: |
Steiner, Kerstin; ACIB GmbH, c/o TU Graz, Petersgasse 14/4, 8010 Graz Schwab, Helmut; ACIB GmbH, c/o TU Graz, Petersgasse 14/4, 8010 Graz and Institute of Molecular Biotechnology, TU Graz, Petersgasse 14/5, 8010 Graz, Austria |
| Fecha: | 2012-10-22 |
| Publicador: | Computacional and structural biotechnology journal |
| Fuente: |
 |
| Tipo: |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article |
| Tema: | No aplica |
| Descripción: | Enzymes are an attractive alternative in the asymmetric syntheses of chiral building blocks. To meet the requirements of industrial biotechnology and to introduce new functionalities, the enzymes need to be optimized by protein engineering. This article specifically reviews rational approaches for enzyme engineering and de novo enzyme design involving structure-based approaches developed in recent years for improvement of the enzymes’ performance, broadened substrate range, and creation of novel functionalities to obtain products with high added value for industrial applications. |
| Idioma: | Inglés |
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