| Título: | Systems biology and metabolic engineering of Arthrospira cell factories |
| Autores: |
Klanchui, Amornpan Vorapreeda, Tayvich Vongsangnak, Wanwipa Kannapho, Chiraphan Cheevadhanarak, Supapon Meechai, Asawin |
| Fecha: | 2012-12-09 |
| Publicador: | Computacional and structural biotechnology journal |
| Fuente: |
 |
| Tipo: |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article |
| Tema: | No aplica |
| Descripción: | Arthrospira are attractive candidates to serve as cell factories for production of many valuable compounds useful for food, feed, fuel and pharmaceutical industries. In connection with the development of sustainable bioprocessing, it is a challenge to design and develop efficient Arthrospira cell factories which can certify effective conversion from the raw materials (i.e. CO2 and sun light) into desired products. With the current availability of the genome sequences and metabolic models of Arthrospira, the development of Arthrospira factories can now be accelerated by means of systems biology and the metabolic engineering approach. Here, we review recent research involving the use of Arthrospira cell factories for industrial applications, as well as the exploitation of systems biology and the metabolic engineering approach for studying Arthrospira. The current status of genomics and proteomics through the development of the genome-scale metabolic model of Arthrospira, as well as the use of mathematical modeling to simulate the phenotypes resulting from the different metabolic engineering strategies are discussed. At the end, the perspective and future direction on Arthrospira cell factories for industrial biotechnology are presented． |
| Idioma: | Inglés |
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FACULTAD DE CIENCIAS QUIMICAS
BENEMERITA UNIVERSIDAD AUTONOMA DE PUEBLA, Puebla, PUE., MEXICO,Lozano-Aponte, Jorge; BENEMERITA UNIVERSIDAD AUTONOMA DE PUEBLA
CIUDAD UNIVERSITARIA C.U.
Laboratorio de Simulaciones moleculares computacionales,
Facultad de Ciencias Quimicas,
14 SUR CON AVENIDA SAN CLAUDIO
C.P. 72570 COLONIA SAN MANUEL
Puebla, PUE., MEXICO,Figueroa-Vazquez, Vianihuini; Department of Hematology and Laboratory for Cellular Therapy, Instituto Maimonides Investigación Biomédica, Cordoba, Spain.,Yunes-Rojas, Julian Alexandro; Departamento de Biotecnología, Tecnológico de Monterrey, campus Puebla, México.,Zähringer, Ulrich,Alexander, Christian; Division of Immunochemistry, Research Center Borstel, Leibniz-Center for Medicine and Biosciences, Borstel,Germany. |