| Título: | The Role of INDY in Metabolic Regulation |
| Autores: |
Willmes, Diana M; Charité University School of Medicine Berlin Birkenfeld, Andreas L; Charité University School of Medicine Berlin |
| Fecha: | 2013-12-08 |
| Publicador: | Computacional and structural biotechnology journal |
| Fuente: |
 |
| Tipo: |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| Tema: | No aplica |
| Descripción: | Reduced expression of the Indy (I’m Not Dead Yet) gene in D. melanogaster and C. elegans extends longevity. Indy and its mammalian homolog mINDY (Slc13a5, NaCT) are transporters of TCA cycle intermediates, mainly handling the uptake of citrate via the plasma membrane into the cytosol. Deletion of mINDY in mice leads to significant metabolic changes akin to caloric restriction, likely caused by reducing the effects of mINDY-imported citrate on fatty acid and cholesterol synthesis, glucose metabolism and ß-oxidation. This review will provide an overview on different mammalian SLC13 family members with a focus on mINDY (SLC13A5) in glucose and energy metabolism and will highlight the role of mINDY as a putative therapeutic target for the treatment of obesity, non-alcoholic fatty liver disease and type 2 diabetes. |
| Idioma: | Inglés |
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FACULTAD DE CIENCIAS QUIMICAS
BENEMERITA UNIVERSIDAD AUTONOMA DE PUEBLA, Puebla, PUE., MEXICO,Lozano-Aponte, Jorge; BENEMERITA UNIVERSIDAD AUTONOMA DE PUEBLA
CIUDAD UNIVERSITARIA C.U.
Laboratorio de Simulaciones moleculares computacionales,
Facultad de Ciencias Quimicas,
14 SUR CON AVENIDA SAN CLAUDIO
C.P. 72570 COLONIA SAN MANUEL
Puebla, PUE., MEXICO,Figueroa-Vazquez, Vianihuini; Department of Hematology and Laboratory for Cellular Therapy, Instituto Maimonides Investigación Biomédica, Cordoba, Spain.,Yunes-Rojas, Julian Alexandro; Departamento de Biotecnología, Tecnológico de Monterrey, campus Puebla, México.,Zähringer, Ulrich,Alexander, Christian; Division of Immunochemistry, Research Center Borstel, Leibniz-Center for Medicine and Biosciences, Borstel,Germany. |