| Título: | Effect of Gender and Age on the Prothrombin Time (PT), Activated Partial Thromboplastin Time (aPTT) Levels and International Normalized Ratio (INR) |
| Autores: |
Sivrikaya, Abdullah; Selcuk University Baran, Hatice; Selcuk University Abusoglu, Sedat; Selcuk University Ozturk, Bahadir; Selcuk University Vatansev, Husamettin; Selcuk University UNLU, Ali; Selcuk University |
| Fecha: | 2013-09-23 |
| Publicador: | International Journal of Mevlana Medical Sciences |
| Fuente: |
 |
| Tipo: |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| Tema: | INR; PT; aPTT; gender; age |
| Descripción: | Prothrombin time (PT), a test for analysis of coagulation extrinsic pathway, is used for disorders of coagulation, to assess the risk of bleeding in patients undergoing operative procedures, monitororing of the patients being treated with oral anticoagulant therapy, and evaluate liver function. Activated partial thromboplastin time (aPTT) is used to determine the function of the intrinsic pathway and common pathway factors. The objective of our study is to examine whether PT, International normalized ratio (INR) and aPTT levels differ between the genders and ages in patients without any known liver disease or anticoagulant drug medication. In this retrospective study, plasma PT, aPTT and PT levels of patients admitted to hospital for various reasons, were analyzed from laboratory information system. 403 males and 403 females were included in the study. Cases were classified according to age as 0-14, 15-50 and over 50 years. PT and INR levels of male patients were significantly higher from the female patients (p = 0.019 and p =0.031 ,respectively). aPTT levels did not differ between genders when total participants evaluated. aPTT levels were significantly lower in men between the age groups 15-50 (p= 0.039), while no significant difference was detected between the age groups 0-14. PT, INR and aPTT levels demonstrated slight differences in certain age and gender groups. Thus, population-based reference intervals should be determined in order to evaluate borderline patients. |
| Idioma: | Inglés |
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