This article explores commercial, academic, and national initiatives aimed at usingsequencing technologies to generate “actionable” genomic results that can beapplied to the clinical management of oncology patients. We argue that the term“actionable” is not merely a buzzword, but signals the…

Researchers and clinicians in the field of oncology have now entered the second decadeof targeted therapy, widely held to be a revolutionary new form of cancer therapyresearch. The present era is regarded as the end of brute empiricism: as laboratoryresearchers…

This article traces the history of research on resistance to drug therapy in oncology using scientometric techniques and qualitative analysis. Using co-citation analysis, we generate maps to visualize subdomains in resistance research in two time periods, 1975–1990 and 1995–2010. These…

The question of rationality and modernity has played a key role in defining the West’sunderstanding of itself in relation to “the other.” Much of this self-defining was done in a waythat privileged a western model of rationality, which itself was…

La separación de biomoléculas de alto valor añadido, con tamaño y características similares como la albúmina de suero bovino (BSA) y la lactoferrina (LF), representa uno de los retos más difíciles en la industria bioquímica. Durante 100 años las técnicas…

Breast Cancer Resistance Protein (BCRP, ABCG2) and P-glycoprotein (P-gp, ABCB1, MDR1) are
members of the G and B subfamily of the ATP-binding cassette (ABC) efflux transporters, respectively.
Both transporters use the energy of ATP hydrolysis for substrate efflux.…

En esta tesis doctoral se propone la utilización de una metodología espacial para la integración de construcciones rurales en su entorno, mediante la utilización de un sistema de evaluación de criterios múltiples (ECM), en un entorno web asistido por la…

Generally, drilling fluids may be multicomponent suspensions, emulsions and/or foams, basically consisting of a base fluid (oil or water), viscosifiers/thinners (clays, biopolymers, etc) and weighting agents (salts) designed to lubricate during drilling operation and removal the cuttings, among others functions.…

In this article we study the retrospective inverse problem. The retrospective inverse problem consists of in the reconstruction of a priori unknown initial condition of the dynamic system from its known final condition. Existence and uniqueness of the solution is…

Concept maps are graphical representations of relationships among concepts that can be an effective tool for teaching, designing, and organizing information in a variety of library settings. Concept maps can be used wherever training or formal teaching occurs as a…