Mild Traumatic Brain Injuries (mTBI) and concussions are complex injuries with high incidence rates in children and adolescents. There currently exists no 'gold standard' for the diagnosis of concussions, and detection and monitoring are made challenging by highly variable clinical…

Multiple sclerosis (MS) is thought to be an autoimmune disease that affects the central nervous system of young adults. Although an uncommon disease in children, recent research has examined the effect of this disease upon a younger demographic group. This…

The Rab superfamily of small GTPases coordinates essentially every step of vesicle trafficking starting from vesicle formation, followed by transport and eventually fusion with the target membrane. Rab proteins are able to regulate such a large range of functions by…

Opioid and α2-adrenergic receptor (α2AR) ligands are both analgesic when administered spinally and show a clinically beneficial synergistic interaction in the treatment of pain when co-administered. The µ- and δ-opioid receptors (MOR and DOR respectively) and the α2AARs have been…