This article explores commercial, academic, and national initiatives aimed at usingsequencing technologies to generate “actionable” genomic results that can beapplied to the clinical management of oncology patients. We argue that the term“actionable” is not merely a buzzword, but signals the…

Researchers and clinicians in the field of oncology have now entered the second decadeof targeted therapy, widely held to be a revolutionary new form of cancer therapyresearch. The present era is regarded as the end of brute empiricism: as laboratoryresearchers…

This article traces the history of research on resistance to drug therapy in oncology using scientometric techniques and qualitative analysis. Using co-citation analysis, we generate maps to visualize subdomains in resistance research in two time periods, 1975–1990 and 1995–2010. These…

Esta investigación enfatiza la importancia del conocimiento matemático del profesorado para garantizar una educación matemática continua. Desde esta perspectiva de continuidad se explora el papel del docente de matemáticas en la transición de primaria a secundaria, un contexto especialmente adecuado…

This essay argues that intellectual historians have overlooked the significance of the return of Euclid’s geometric thought to early-modern Europe. Looking at the period between 1400 and 1800, this essay shows how geometric thought not only penetrated into fundamental areas…

Esta tesis presenta una particularización de la Gestión del Conocimiento Matemático al caso de la Topología Algebraica.
La Gestión del Conocimiento Matemático es una rama de las Ciencias de la Computación cuyo principal objetivo consiste en desarrollar asistentes para…

Nowadays large systems are viewed in terms of the services that they offer and the entities that interact to provide or consume these services. Open multi-agent systems, where agents can enter or leave the system, interact and dynamically form groups…

Software technology is creating a ubiquitous context for human living and learning in which new modes of interaction are gradually being incorporated. At the same time, interaction with Internet-based learning systems has evolved from using the traditional access from a…

Following a classical conception of Artificial Intelligence (one that aims a definition of cognitive mechanisms and their implementation in computers), this thesis explores the problem of knowledge organization. In particular, it draws attention to the linguistic and semantic memory, trying…

Total internal reflection microscopy (TIRM) measures the position of a Brownian particle above an interface by using its scattering of an evanescent wave. From the knowledge of the trajectory it is possible to reconstruct the interaction potential between the Brownian…