This article explores commercial, academic, and national initiatives aimed at usingsequencing technologies to generate “actionable” genomic results that can beapplied to the clinical management of oncology patients. We argue that the term“actionable” is not merely a buzzword, but signals the…

Researchers and clinicians in the field of oncology have now entered the second decadeof targeted therapy, widely held to be a revolutionary new form of cancer therapyresearch. The present era is regarded as the end of brute empiricism: as laboratoryresearchers…

This article traces the history of research on resistance to drug therapy in oncology using scientometric techniques and qualitative analysis. Using co-citation analysis, we generate maps to visualize subdomains in resistance research in two time periods, 1975–1990 and 1995–2010. These…

This paper is the survey of studies that include design processes of some fuzzy expert systems for applications in some medical area. Recent studies of us that include fuzzy expert systems that make use of fuzzy logic method were described.…

Diabetes mellitus represents a serious public health problem owing to its global prevalence in the last decade. The causes of this metabolic disease include dysfunction and/or insufficient number of b cells. Existing diabetes mellitus treatments do not reverse or control…

Beginning with the premise that colonialism and the production of knowledge are intimately related, Christopher Schmidt-Nowara’s interests in this book lie in the versions of national and imperial histories elaborated by nineteenth-century Spanish and Antillean intellectuals. The production of knowledge…

The Caribbean Basin has complex biogeographical and cultural histories that have shaped its highly diverse botanical and cultural landscapes. As a result, the current ethnic composition of the Basin is a heterogeneous mixture including Amerindian, Afrocaribbean and a wide range…

NAC proteins constitute one of the largest groups of plant-specific transcription factors and are known to play essential roles in various developmental processes. They are also important in plant responses to stresses such as drought, soil salinity, cold, and heat,…

Knowledge on the biosynthetic pathways of the monoter­pene alkaloids is enormous, but little is known about their mechanism of transporting system from the plant cell. There is not concrete evi­dence confirming the role of ABC transporters in the secretion of monoterpene indole alkaloids (MIAs) in Catharanthus roseus. There­fore, in order to determine the role of different transporting systemsinvolved in the MIAs translocation, we employed…

This article aims at identifying and characterizing the different configurations of the relevant factors related to administrative procedures, in order to learn about their behavior, and so about decision-making processes. Delays in administrative circuit concretion, users dissatisfaction and lack of…