This article explores commercial, academic, and national initiatives aimed at usingsequencing technologies to generate “actionable” genomic results that can beapplied to the clinical management of oncology patients. We argue that the term“actionable” is not merely a buzzword, but signals the…

Researchers and clinicians in the field of oncology have now entered the second decadeof targeted therapy, widely held to be a revolutionary new form of cancer therapyresearch. The present era is regarded as the end of brute empiricism: as laboratoryresearchers…

This article traces the history of research on resistance to drug therapy in oncology using scientometric techniques and qualitative analysis. Using co-citation analysis, we generate maps to visualize subdomains in resistance research in two time periods, 1975–1990 and 1995–2010. These…

In this article we study the retrospective inverse problem. The retrospective inverse problem consists of in the reconstruction of a priori unknown initial condition of the dynamic system from its known final condition. Existence and uniqueness of the solution is…

Torres-Saillant’s book contends, as its author explains, that as a region the Caribbean is a differentiated “civilizational” zone produced by the encounter of multiple cultures and by contending political and economic interests. This region, according to him, has produced an…

Research studying effective planning and optimization in the vehicle routing field has increased tremendously in the last few decades. Advances in technology and computational power have encouraged researchers to consider various vehicle routing problem types and constraints, and to experiment…

This essay contests the view that humanity’s centuries-long experience with clocks is marked by a steady increase in time awareness that culminated in the modern compulsion known as “time discipline”. It argues, in contrast, that modern time discipline emerged during…

Electoral authoritarian regimes represent the modal type of political regimes in the developing world. To control electoral outcomes, such regimes may deploy a broad variety of repressive and manipulative measures. Despite their empirical as well as normative relevance, we possess…

"We shortly recall the mathematical and physical aspects of Talbot’s self-imaging effect occurring in near-field diffraction. In the rational paraxial approximation, the Talbot images are formed at distances z = p/q, where p and q are coprimes, and are superpositions…

The objective of this research is to elaborate an endogenous growth
model which allows us to examine the mutual interaction between economic
growth, labour market behaviour and population growth. We show how the
introduction of disequilibrium and some nonlinearities give…