The question of rationality and modernity has played a key role in defining the West’sunderstanding of itself in relation to “the other.” Much of this self-defining was done in a waythat privileged a western model of rationality, which itself was…

Good command of anatomy is a basic requirement for studying and practicing clinical disciplines. A common difficulty that faces many medical and dental students (at least this was the case with the author) is how to keep their knowledge of…

This article explores commercial, academic, and national initiatives aimed at usingsequencing technologies to generate “actionable” genomic results that can beapplied to the clinical management of oncology patients. We argue that the term“actionable” is not merely a buzzword, but signals the…

Researchers and clinicians in the field of oncology have now entered the second decadeof targeted therapy, widely held to be a revolutionary new form of cancer therapyresearch. The present era is regarded as the end of brute empiricism: as laboratoryresearchers…

This article traces the history of research on resistance to drug therapy in oncology using scientometric techniques and qualitative analysis. Using co-citation analysis, we generate maps to visualize subdomains in resistance research in two time periods, 1975–1990 and 1995–2010. These…

The way frailty is conceptualised and interpreted has profound implications for social responses, care practice and the personal experience of care. This paper begins with an exegesis of the concept of frailty, and then examines the dominant notions of frailty,…

Open Source Software projects base their operation on collaborative structure for knowledge exchange in the form of provision or reception of information, expertise and feedback on the creation of source code. Here, we address the direction of these knowledge flows…

La separación de biomoléculas de alto valor añadido, con tamaño y características similares como la albúmina de suero bovino (BSA) y la lactoferrina (LF), representa uno de los retos más difíciles en la industria bioquímica. Durante 100 años las técnicas…

This article aims at identifying and characterizing the different configurations of the relevant factors related to administrative procedures, in order to learn about their behavior, and so about decision-making processes. Delays in administrative circuit concretion, users dissatisfaction and lack of…

Breast Cancer Resistance Protein (BCRP, ABCG2) and P-glycoprotein (P-gp, ABCB1, MDR1) are
members of the G and B subfamily of the ATP-binding cassette (ABC) efflux transporters, respectively.
Both transporters use the energy of ATP hydrolysis for substrate efflux.…