This article explores commercial, academic, and national initiatives aimed at usingsequencing technologies to generate “actionable” genomic results that can beapplied to the clinical management of oncology patients. We argue that the term“actionable” is not merely a buzzword, but signals the…

Researchers and clinicians in the field of oncology have now entered the second decadeof targeted therapy, widely held to be a revolutionary new form of cancer therapyresearch. The present era is regarded as the end of brute empiricism: as laboratoryresearchers…

This article traces the history of research on resistance to drug therapy in oncology using scientometric techniques and qualitative analysis. Using co-citation analysis, we generate maps to visualize subdomains in resistance research in two time periods, 1975–1990 and 1995–2010. These…

This essay contests the view that humanity’s centuries-long experience with clocks is marked by a steady increase in time awareness that culminated in the modern compulsion known as “time discipline”. It argues, in contrast, that modern time discipline emerged during…

Electoral authoritarian regimes represent the modal type of political regimes in the developing world. To control electoral outcomes, such regimes may deploy a broad variety of repressive and manipulative measures. Despite their empirical as well as normative relevance, we possess…

"We shortly recall the mathematical and physical aspects of Talbot’s self-imaging effect occurring in near-field diffraction. In the rational paraxial approximation, the Talbot images are formed at distances z = p/q, where p and q are coprimes, and are superpositions…

The question of rationality and modernity has played a key role in defining the West’sunderstanding of itself in relation to “the other.” Much of this self-defining was done in a waythat privileged a western model of rationality, which itself was…

The objective of this research is to elaborate an endogenous growth
model which allows us to examine the mutual interaction between economic
growth, labour market behaviour and population growth. We show how the
introduction of disequilibrium and some nonlinearities give…

The study of natural fluctuations has been of great interest for
economists for decades. Although the earliest formal models of business
cycles, around the 1950s, were endogenous (Hicks, Kaldor, Goodwin), the
dominant strategy during the most of the last century…

Physical orientation was a central philosophical problem for German thinkers in the late eighteenth century. Moses Mendelssohn, for instance, pondered in Morgenstunden, o Vorlesungen uber das Daseyn Gotten (1785) whether one can orient oneself in the metaphysical realm with the…