This article explores commercial, academic, and national initiatives aimed at usingsequencing technologies to generate “actionable” genomic results that can beapplied to the clinical management of oncology patients. We argue that the term“actionable” is not merely a buzzword, but signals the…

Researchers and clinicians in the field of oncology have now entered the second decadeof targeted therapy, widely held to be a revolutionary new form of cancer therapyresearch. The present era is regarded as the end of brute empiricism: as laboratoryresearchers…

This article traces the history of research on resistance to drug therapy in oncology using scientometric techniques and qualitative analysis. Using co-citation analysis, we generate maps to visualize subdomains in resistance research in two time periods, 1975–1990 and 1995–2010. These…

Good command of anatomy is a basic requirement for studying and practicing clinical disciplines. A common difficulty that faces many medical and dental students (at least this was the case with the author) is how to keep their knowledge of…

The way frailty is conceptualised and interpreted has profound implications for social responses, care practice and the personal experience of care. This paper begins with an exegesis of the concept of frailty, and then examines the dominant notions of frailty,…

This study investigates the importance of traditional hunting knowledge to Cree identity and experience. My fieldwork was conducted in Wemindji, James Bay, Quebec, with Cree trappers and on the interactions of scientific researchers and Cree trappers. I explore the connections…

This research project investigates the nature of university professors' discipline-specific pedagogical knowledge (DPK). Traditionally, DPK has been examined with the help of constructs from two distinct lines of research: the knowledge base for teaching and disciplinary specificity in university teaching.…

The purpose of this study was to investigate sources of knowledge acquisition of high school team sport coaches. Six teacher/coaches were interviewed using a semi-structured open-ended interview format. Cote, Salmela, and Russell's (1995) guidelines were used to inductively analyze and…

In this thesis we follow two directions: Zero Knowledge Protocols and the Discrete Logarithm Problem. In each direction we present the necessary background and we give a new approach for some parts of the existing protocols., The new parts are…

Metacognitive knowledge is a critical piece of the information literacy puzzle. In a world of exploding information and communications possibilities, the difficulty for users of information systems and services may not lie in finding information but in filtering and integrating…