This article explores commercial, academic, and national initiatives aimed at usingsequencing technologies to generate “actionable” genomic results that can beapplied to the clinical management of oncology patients. We argue that the term“actionable” is not merely a buzzword, but signals the…

Researchers and clinicians in the field of oncology have now entered the second decadeof targeted therapy, widely held to be a revolutionary new form of cancer therapyresearch. The present era is regarded as the end of brute empiricism: as laboratoryresearchers…

This article traces the history of research on resistance to drug therapy in oncology using scientometric techniques and qualitative analysis. Using co-citation analysis, we generate maps to visualize subdomains in resistance research in two time periods, 1975–1990 and 1995–2010. These…

This thesis studies al-Ghazali's theory of knowledge, particularly his concept of knowledge of God in his three later works: "The book of Knowledge" of the Ih&dotbelow;ya', al-Munqidh, and Iljam al-`Awamm. From his conception of knowledge of God the first book…

The contemporary study in the philosophy of language concentrates extensively on a cluster of questions defining the problem of linguistic knowledge (Evans 1981, Davies 1989, Dummett 1991). What explains a speaker's language mastery? Is it knowledge that underwrites our linguistic…

One of the more recent and alluring phrases used by development and resource management practitioners and theorists is "traditional ecological knowledge." Although there is a substantial amount of the literature on this subject, these studies have unfortunately an inadequate characterization…

While theory formation and the relation between theory and data has been investigated in many studies of scientific reasoning, researchers have focused less attention on reasoning about experimental design, even though the experimental design process makes up a large part…

The purpose of this study is to investigate a series of issues around the primary theme of value constructions and the ways that these influence the construction of interior spaces and impact on its occupants. The ways in which knowledge…

Focusing on the A-text (1604) version of Marlowe's Doctor Faustus , this study further assesses biographical information on the poet and intellectual currents of the Counter Reformation, so as to investigate the play's relation to emergent trends of individualism in…

This thesis considers the design of receivers for multi-user communication systems based on asynchronous direct-sequence code-division multiple-access (DS-CDMA). Its primary aim is to improve current receiver designs which exhibit shortcomings in systems using long sequence spreading (where the spreading sequence…