This article explores commercial, academic, and national initiatives aimed at usingsequencing technologies to generate “actionable” genomic results that can beapplied to the clinical management of oncology patients. We argue that the term“actionable” is not merely a buzzword, but signals the…

Researchers and clinicians in the field of oncology have now entered the second decadeof targeted therapy, widely held to be a revolutionary new form of cancer therapyresearch. The present era is regarded as the end of brute empiricism: as laboratoryresearchers…

This article traces the history of research on resistance to drug therapy in oncology using scientometric techniques and qualitative analysis. Using co-citation analysis, we generate maps to visualize subdomains in resistance research in two time periods, 1975–1990 and 1995–2010. These…

The bulk of research on teacher knowledge has taken place in elementary and secondary school settings. The goal of this study was to examine teacher knowledge in higher education by asking: (1) what types of knowledge are drawn upon in…

A major contribution of research in workplace literacy has been to explore the part that writing plays in the knowledge-making practices of various professional groups. While such enquiry has revealed that writing is essential to the creation and use of…

This study examined the efficacy of conjoint behavioural consultation (CBC) with children evidencing conduct problems, the impact of CBC in enhancing parental knowledge of behavioural principles, and whether knowledge of behavioural principles is related to improved parenting skills. An A/B…

The structural design of power transmission lines requires knowledge from a variety of widely-dispersed expert sources. This thesis demonstrates how an expert system can be efficiently used to assemble and organize this knowledge in order to design a wide range…

Over the past few years, the amount of electronic information available from the Internet has increased dramatically. Unfortunately, the search tools currently available for retrieving and filtering such information remain inadequate in balancing relevance and comprehensiveness. This work proposes a…

This thesis argues that women's bodies are constituted by discourses about them. It explores the operations of power over women's bodies by analyzing the way in which the maternal body is constructed in the discourses of law, medicine and culture.…

In order to investigate the use of fuzzy logic in decision-support systems (DSS) for dairy cattle breeding, a first-generation prototype software system was developed. The objectives were to determine the advantages and limitations of fuzzy logic for this type of…