This article explores commercial, academic, and national initiatives aimed at usingsequencing technologies to generate “actionable” genomic results that can beapplied to the clinical management of oncology patients. We argue that the term“actionable” is not merely a buzzword, but signals the…

Researchers and clinicians in the field of oncology have now entered the second decadeof targeted therapy, widely held to be a revolutionary new form of cancer therapyresearch. The present era is regarded as the end of brute empiricism: as laboratoryresearchers…

This article traces the history of research on resistance to drug therapy in oncology using scientometric techniques and qualitative analysis. Using co-citation analysis, we generate maps to visualize subdomains in resistance research in two time periods, 1975–1990 and 1995–2010. These…

The Caribbean Basin has complex biogeographical and cultural histories that have shaped its highly diverse botanical and cultural landscapes. As a result, the current ethnic composition of the Basin is a heterogeneous mixture including Amerindian, Afrocaribbean and a wide range…

Diabetes mellitus represents a serious public health problem owing to its global prevalence in the last decade. The causes of this metabolic disease include dysfunction and/or insufficient number of b cells. Existing diabetes mellitus treatments do not reverse or control…

In this paper we consider boundary value problems with singularity in equation or solution. To solve these problems, we apply single exponential and double exponential transformations of sinc-Galerkin and Chebyshev cardinal functions. Numerical examples highlight efficiency of Chebyshev cardinal functions…

NAC proteins constitute one of the largest groups of plant-specific transcription factors and are known to play essential roles in various developmental processes. They are also important in plant responses to stresses such as drought, soil salinity, cold, and heat,…

Knowledge on the biosynthetic pathways of the monoter­pene alkaloids is enormous, but little is known about their mechanism of transporting system from the plant cell. There is not concrete evi­dence confirming the role of ABC transporters in the secretion of monoterpene indole alkaloids (MIAs) in Catharanthus roseus. There­fore, in order to determine the role of different transporting systemsinvolved in the MIAs translocation, we employed…

In a world in which markets are more globalised and continuously evolving, industry need new tools to enhance their flexibility and maintain competitiveness. A key strategy is discovering useful knowledge through the information gathered from production processes. In recent decades,…

Descripción completa.