This article explores commercial, academic, and national initiatives aimed at usingsequencing technologies to generate “actionable” genomic results that can beapplied to the clinical management of oncology patients. We argue that the term“actionable” is not merely a buzzword, but signals the…

Researchers and clinicians in the field of oncology have now entered the second decadeof targeted therapy, widely held to be a revolutionary new form of cancer therapyresearch. The present era is regarded as the end of brute empiricism: as laboratoryresearchers…

This article traces the history of research on resistance to drug therapy in oncology using scientometric techniques and qualitative analysis. Using co-citation analysis, we generate maps to visualize subdomains in resistance research in two time periods, 1975–1990 and 1995–2010. These…

Four teachers & their eight classes of 179 5th-grade (10-11-year-old) students participated in this quasi-experimental classroom study, which investigated the effects of form-focused instruction (FFI) & corrective feedback on immersion students' ability to accurately assign grammatical gender in French. The…

The way frailty is conceptualised and interpreted has profound implications for social responses, care practice and the personal experience of care. This paper begins with an exegesis of the concept of frailty, and then examines the dominant notions of frailty,…

When Alexander Dent arrived in Brazil in 1998, he was unaware of the existence of the rural genres that are the focus of this book. He had listened to bossa nova, MPB, Tropicália, death metal, forró, and techno, among other…

Introduction: The use of computer-generated 3-dimensional (3-D) anatomical models to teach anatomy has proliferated. However, there is little evidence that these models are educationally effective. The purpose of this study was to test the educational effectiveness of a computer-generated 3-D…

Open Source Software projects base their operation on collaborative structure for knowledge exchange in the form of provision or reception of information, expertise and feedback on the creation of source code. Here, we address the direction of these knowledge flows…

La separación de biomoléculas de alto valor añadido, con tamaño y características similares como la albúmina de suero bovino (BSA) y la lactoferrina (LF), representa uno de los retos más difíciles en la industria bioquímica. Durante 100 años las técnicas…

Breast Cancer Resistance Protein (BCRP, ABCG2) and P-glycoprotein (P-gp, ABCB1, MDR1) are
members of the G and B subfamily of the ATP-binding cassette (ABC) efflux transporters, respectively.
Both transporters use the energy of ATP hydrolysis for substrate efflux.…