| Título: | The genetic basis of melanism in the gray squirrel (Sciurus carolinensis) |
| Autores: |
McRobie, Helen Thomas, Alison Kelly, Jo |
| Fecha: |
2013-09-16 2013-09-16 2009-07-30 |
| Publicador: | Anglia Ruskin University |
| Fuente: |
 |
| Tipo: | Article |
| Tema: |
melanism Melanocortin-1 receptor sciurus carolinensis MC1R gray squirrel |
| Descripción: | The black squirrel is a melanic variant of the gray squirrel (Sciurus carolinensis). We found 3 coat color variants in the gray squirrel: the wild-type gray, a jet-black, and a brown–black phenotype. These 3 morphs are due to varying distributions of eumelanin and phaeomelanin pigment in hairs. The melanocortin 1 receptor (MC1R) plays a central role in regulating eumelanin and phaeomelanin production. We sequenced the MC1R gene for all 3 coat color phenotypes and found a 24 base-pair deletion. The gray phenotype was homozygous for the wild-type allele Eþ, the jet-black phenotype was homozygous for the MC1R-D24 allele EB, and the brown–black phenotype was heterozygous for the Eþ and EB alleles. We conclude that melanism in gray squirrels is associated with the MC1R-D24 EB allele at amino acid positions 87–94 and that this allele is incompletely dominant to the wild-type allele. We predict that the MC1R-D24 EB allele encodes a constitutively active or hyperactive receptor. |
| Idioma: | Inglés |
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