Título: Development of a harmonised method for the profiling of amphetamines: II. Stability of impurities in organic solvents
Autores: Aalberg, Laura
Andersson, Kjell
Bertler, Christina
Cole, Michael D.
Finnon, Yvonne
Huizer, Henk
Jalava, Kaisa
Kaa, Elisabet
Lock, Eric
Lopes, Alvaro
Poortman-van der Meer, Anneke
Sippola, Erkki
Dahlén, Johan
Fecha: 2010-05-05
2010-05-05
2005-05
Publicador: Anglia Ruskin University
Fuente:
Tipo: Article
Tema: amphetamine profiling
stability
extraction
impurities
organic solvent
Descripción: The present study focused on the stability of 22 amphetamine impurities dissolved in six organic solvents: isooctane, toluene, ethanol, dichloromethane, ethyl acetate, and diethyl ether. The aim was to find the most inert, and thereby most suitable, solvent for amphetamine profiling. Mixtures of the impurities were prepared in the different solvents, and changes in the concentrations of the individual compounds over-time were monitored by gas chromatographic analysis after 0, 4, 12, 24, 48, and 96 h. Isooctane and toluene provided the most inert conditions, although, a few of the impurities were insufficiently stable in these two solvents. The present experiments were performed as a part of the development of a harmonised method for profiling of amphetamine. The results can be used to support the choice of organic solvents for sample preparation. They also provide information about the stability of the impurities that are found in profiles of illicit amphetamine. This is essential due to the fact, that unstable compounds can have a negative influence on the comparison of profiles.
Idioma: Inglés

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