| Título: | Decreased poly(ADP-ribosyl)ation of CTCF, a transcription factor, is associated with breast cancer phenotype and cell proliferation |
| Autores: |
Docquier, France Kita, Georgia-Xanthi Farrar, Dawn Jat, Parmjit O'Hare, Michael Chernukhin, Igor Gretton, Svetlana Mandal, Adhip Alldridge, Louise Klenova, Elena |
| Fecha: |
2011-09-20 2011-09-20 2009-09-15 |
| Publicador: | Anglia Ruskin University |
| Fuente: |
 |
| Tipo: | Article |
| Tema: |
CTCF poly(ADP-ribosyl)ation breast cancer |
| Descripción: | There is compelling evidence of a relationship between poly(ADP-ribosyl)ation and tumorigenesis; however, much less is known about the role of specific targets of poly(ADP-ribosyl)ation in tumor development. Two forms of the multifunctional transcription factor, CTCF, were previously identified: a 130-kDa protein (CTCF-130), characteristic for cell lines, and a 180-kDa protein (CTCF-180), modified by poly(ADP-ribosyl)ation. This study was aimed to investigate differential poly(ADP-ribosyl)ation of CTCF in normal and tumor breast tissues. |
| Idioma: | Inglés |
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