Mutations in the parkin gene are responsible for an early-onset autosomal-recessive form of Parkinson's disease. Parkin is an E3 ubiquitin ligase that acts in the covalent attachment of the small protein ubiquitin to substrate proteins. Although many parkin substrates have…

Safety and health is a basic human need and when not met, exacts costs that prevent societies from realizing development goals. Injury is increasing as a leading cause of death and disability. As the result of advances in public health…

The incorporation of temporally extended actions, or options , into the reinforcement learning framework has proven to be useful in planning and knowledge representation. Options provide a form of temporal abstraction, as they represent courses of action of variable duration.…

"Model Driven Software Development" is a recent trend in development of software-intensive systems. In the Model Driven Software Development process, all knowledge pertaining to the software system to be built is represented in the form of models, in the right…

People are efficient when they make decisions under uncertainty, even when their decisions have long-term ramifications, or when their knowledge and their perception of the environment are uncertain. We are able to experiment with the environment and learn, improving our…

This paper examines and compares the different ways in which Charles Taylor and Richard Rorty critique the representationalism and foundationalism characteristic of modern epistemology (Chapter One), then considers how their critiques affect their respective understandings of morality (Chapter Two) and…

This thesis examines the construction of identity in the pseudepigraphic novel Joseph and Aseneth by means of discussions of conversion, food ritual, and genre. Each of these is invaluable for interpreting the meaning and significance of the honeycomb scene in…

The most ordinary man or woman has means of knowledge concerning his own feelings and circumstances that immeasurably surpass those that anyone else can have.-John Stuart Mill, On Liberty, One feature that varies within competing conceptions of medical shared decision-making…

This thesis presents a method to visually detect and recognize fingering gestures of the left hand of a guitarist. The choice of computer vision to perform that task is motivated by the absence of a satisfying method for realtime guitarist…

This study investigates the use of a new literacy software ABRACADABRA with pre-reading kindergarten students. The participants ( n=27) from one school were assigned randomly to one intervention group (rime or phoneme) and (n=17) school two served as a control.…