Mutations in the parkin gene are responsible for an early-onset autosomal-recessive form of Parkinson's disease. Parkin is an E3 ubiquitin ligase that acts in the covalent attachment of the small protein ubiquitin to substrate proteins. Although many parkin substrates have…

Signaling by growth factors from the TGFbeta/activin has a profound impact on cancer development. They can either negatively regulate tumor development by their ability to inhibit cell growth, induce apoptosis and limit the number of cell divisions through inhibition of…