A cis-regulatory module (CRM) is a DNA region of a few hundred base pairs that consists of clustering of several transcription factor binding sites and regulates the expression of a nearby gene. This thesis presents a new computational approach to…

The statistical evaluation of diagnostic tests may be affected by several potential biases. These biases include those caused by a study design that results in a non-representative sub-sample who are further verified by the reference test (verification bias), and those…

Natural ecosystems are dynamic and complex, with many being threatened by human activity. However, humans can also be at the root of a solution to this problem by developing ecosystem engineering which can be used to design, construct, modify, upgrade,…

Narratives play a significant role in many computer games, and this is especially true in genres such as role-playing and adventure games. Even so, many games have narratives which possess a certain number of flaws that can deteriorate the playing…

When faced with a new design problem, Engineers most often tend to rely on their accumulated knowledge of science, mathematics, and appropriate experience to reach suitable solutions. Case-Based Reasoning is a new engineering paradigm that reflects this fact by suggesting…

The objective of this research is to elaborate an endogenous growth
model which allows us to examine the mutual interaction between economic
growth, labour market behaviour and population growth. We show how the
introduction of disequilibrium and some nonlinearities give…

The study of natural fluctuations has been of great interest for
economists for decades. Although the earliest formal models of business
cycles, around the 1950s, were endogenous (Hicks, Kaldor, Goodwin), the
dominant strategy during the most of the last century…

clk-1 encodes a hydroxylase that is necessary for ubiquinone (UQ) biosynthesis. clk-1 mutants do not synthesize UQ, but instead accumulate the precursor demethoxyubiquinone (DMQ). When fed on bacteria that synthesize UQ the mutants are viable but display slow development, behaviours…

This thesis explores China's relations with Kazakhstan, Kyrgyzstan, Tajikistan, Turkmenistan, and Uzbekistan, from 1991 to 2005, contributing to the body of knowledge by arguing that China's relations with post-Soviet Central Asia were shaped by security and economic imperatives in Xinjiang,…

The brain areas required for latent learning in the rat are not currently understood. Previous tasks used to assess latent learning, defined as the acquisition of neutral information that does not immediately influence behavior, have shared characteristics that prevented their…