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Aproximadamente 17 registro(s) hasta el momento: (journal)

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Recurso libre

Meeting report: The seventh conference of the Hellenic Society for Computational Biology and Bioinformatics
Hamodrakas, Stavros J; University of Athens - Iliopoulos, Ioannis; University of Crete - Ouzounis, Christos A; Centre for Research & Technology Hellas AND Donelly Centre for Cellular & Biomolecular Research, University of Toronto - Bagos, Pantelis G; University of Central Greece - Promponas, Vasilis J; University of Cyprus

Formato:	info:eu-repo/semantics/article, info:eu-repo/semantics/publishedVersion,
Enlaces:	-
Fecha:	2013-06-16
Recurso:	Computacional and structural biotechnology journal

Recurso libre

The biological microprocessor, or how to build a computer with biological parts
Moe-Behrens, Gerd HG; Leukippos Institute for Synthetic Biology

Formato:	info:eu-repo/semantics/article, info:eu-repo/semantics/publishedVersion, Peer-reviewed Article
Enlaces:	Systemics, a revolutionary paradigm shift in scientific thinking, with applications in systems biology, and synthetic biology, have led to the idea of using silicon computers and their engineering principles as a blueprint for the engineering of a similar machine made…
Fecha:	2013-06-26
Recurso:	Computacional and structural biotechnology journal

Recurso libre

Spectral Deconvolution for Gas Chromatography Mass Spectrometry-Based Metabolomics: Current Status and Future Perspectives
Du, Xiuxia; University of North Carolina at Charlotte - Zeisel, Steven H; University of North Carolina at Chapel Hill

Formato:	info:eu-repo/semantics/article, info:eu-repo/semantics/publishedVersion, Peer-reviewed Article
Enlaces:	Mass spectrometry coupled to gas chromatography (GC-MS) has been widely applied in the field of metabolomics. Success of this application has benefited greatly from computational workflows that process the complex raw mass spectrometry data and extract the qualitative and quantitative…
Fecha:	2013-06-28
Recurso:	Computacional and structural biotechnology journal

Recurso libre

The Use of Hammett Constants to Understand the Non-Covalent Binding of Aromatics
Lewis, Michael; Saint Louis University - Bagwill, Christina; Saint Louis University - Hardebeck, Laura K. E.; Saint Louis University - Wireduaah, Selina; Saint Louis University

Formato:	info:eu-repo/semantics/article, info:eu-repo/semantics/publishedVersion, Peer-reviewed Article
Enlaces:	Non-covalent interactions of aromatics are important in a wide range of chemical and biological applications. The past two decades have seen numerous reports of arene-arene binding being understood in terms Hammett substituent constants, and similar analyses have recently been extended…
Fecha:	2012-03-06
Recurso:	Computacional and structural biotechnology journal

Recurso libre

The role of Lipoxin A4 in Cystic Fibrosis Lung Disease
Urbach, Valérie; Institut National de la Santé et de la Recherche Médicale - Higgins, Gerard; The National Children's Research Centre, Dublin - Buchanan, Paul; The National Children's Research Centre, Dublin - Ringholz, Fiona; The National Children's Research Centre

Formato:	info:eu-repo/semantics/article, info:eu-repo/semantics/publishedVersion,
Enlaces:	In Cystic Fibrosis (CF), mutations of the CFTR gene result in defective Cl- secretion and Na+ hyperabsorption by epithelia which leads to airway lumen dehydration and mucus plugging and favours chronic bacterial colonization, persistent inflammation and progressive lung destruction. Beyond…
Fecha:	2013-12-06
Recurso:	Computacional and structural biotechnology journal

Recurso libre

Automated detection of structural alerts (chemical fragments) in (eco)toxicology
Lepailleur, Alban; CERMN, University of Caen Basse Normandie France - Poezevara, Guillaume - Bureau, Ronan; CERMN, University of Caen Basse Normandie France

Formato:	info:eu-repo/semantics/article, info:eu-repo/semantics/publishedVersion, Peer-reviewed Article
Enlaces:	This mini-review describes the evolution of different algorithms dedicated to the automated discovery of chemical fragments associated to (eco)toxicological endpoints. These structural alerts correspond to one of the most interesting approach of in silico toxicology due to their direct link…
Fecha:	2013-04-06
Recurso:	Computacional and structural biotechnology journal

Recurso libre

MD simulation studies to investigate iso-energetic conformational behaviour of modified nucleosides m2G and m22G present in tRNA
Bavi, Rohit S - Sambhare, Susmit B - Sonawane, Kailas D; Structural Bioinformatics Unit, Department of Biochemistry, Shivaji University, Kolhapur 416 004, Maharashtra (M.S.), India.

Formato:	info:eu-repo/semantics/article, info:eu-repo/semantics/publishedVersion, Peer-reviewed Article
Enlaces:	Modified nucleic acid bases are most commonly found in tRNA. These may contain modifications from simple methylation to addition of bulky groups. Methylation of the four canonical nucleotide bases at a wide variety of positions is particularly prominent among the…
Fecha:	2013-06-08
Recurso:	Computacional and structural biotechnology journal

Recurso libre

A method to predict edge strands in beta-sheets from protein sequences
Guilloux, Antonin - Caudron, Bernard - Jestin, Jean-Luc

Formato:	info:eu-repo/semantics/article, info:eu-repo/semantics/publishedVersion, Peer-reviewed Article
Enlaces:	There is a need for rules allowing three-dimensional structure information to be derived from protein sequences. In this work, consideration of an elementary protein folding step allows protein sub-sequences which optimize folding to be derived for any given protein sequence.…
Fecha:	2013-06-19
Recurso:	Computacional and structural biotechnology journal

Recurso libre

Searching for Electrical Properties, Phenomena and Mechanisms in the Construction and Function of Chromosomes
Kanev, Ivan; Human Genetics Laboratories, Munroe-Meyer Institute for Genetics and Rehabilitation, University of Nebraska Medical Center - Mei, Wai-Ning - Mizuno, Akira - DeHaai, Kristi - Sanmann, Jennifer - Hess, Michelle - Starr, Lois - Grove, Jennifer - Dave, Bhavana - Sanger, Warren

Formato:	info:eu-repo/semantics/article, info:eu-repo/semantics/publishedVersion,
Enlaces:	Our studies reveal previously unidentified electrical properties of chromosomes: (1) chromosomes are amazingly similar in construction and function to electrical transformers; (2) chromosomes possess in their construction and function, components similar to those of electric generators, conductors, condensers, switches, and…
Fecha:	2013-06-27
Recurso:	Computacional and structural biotechnology journal

Recurso libre

10.

Methods for recombinant expression and functional characterization of human cannabinoid receptor CB2
Yeliseev, Alexei A; National Institutes of Health

Formato:	info:eu-repo/semantics/article, info:eu-repo/semantics/publishedVersion,
Enlaces:	Cannabinoid receptor CB2 is a seven transmembrane-domain integral membrane protein that belongs to a large superfamily of G protein-coupled receptors (GPCR). CB2 is a part of the endocannabinoid system that plays vital role in regulation of immune response, inflammation, pain…
Fecha:	2013-09-06
Recurso:	Computacional and structural biotechnology journal

Recurso libre

11.

LC-MS metabolomics from study design to data-analysis – using a versatile pathogen as a test case
Berg, Maya; Institute of Tropical Medicine Antwerp - Vanaerschot, Manu; Institute of Tropical Medicine Antwerp - Jankevics, Andris; University of Glasgow and University of Groningen - Cuypers, Bart; Institute of Tropical Medicine Antwerp - Breitling, Rainer; University of Manchester - Dujardin, Jean-Claude; Institute of Tropical Medicine Antwerp

Formato:	info:eu-repo/semantics/article, info:eu-repo/semantics/publishedVersion, Peer-reviewed Article
Enlaces:	Thanks to significant improvements in LC-MS technology, metabolomics is increasingly used as a tool to discriminate the responses of organisms to various stimuli or drugs. In this minireview we discuss all aspects of the LC-MS metabolomics pipeline, using a complex…
Fecha:	2013-02-06
Recurso:	Computacional and structural biotechnology journal

Recurso libre

12.

Changes in the genome-wide localization pattern of Sir3 in Saccharomyces cerevisiae during different growth stages
Tung, Shu-Yun; Academia Sinica - Lee, Kuan-Wei; National Health Research Institutes - Hong, Jia-Yang; National Health Research Institutes - Lee, Sue-Ping; Academia Sinica - Shen, Hsiao-Hsuian; National Health Research Institutes - Liou, Gunn-Guang; National Health Research Institutes

Formato:	info:eu-repo/semantics/article, info:eu-repo/semantics/publishedVersion, Peer-reviewed Article
Enlaces:	In budding yeast, the Sir2, Sir3 and Sir4 proteins form SIR complexes, required for the assembly of silent heterochromatin domains, and which mediate transcription silencing at the telomeres as well as at silent mating type loci. In this study, under…
Fecha:	2013-06-19
Recurso:	Computacional and structural biotechnology journal

Recurso libre

13.

Robustness in experimental design: A study on the reliability of selection approaches
Brandmaier, Stefan - Tetko, Igor V

Formato:	info:eu-repo/semantics/article, info:eu-repo/semantics/publishedVersion, Peer-reviewed Article
Enlaces:	The quality criteria for experimental design approaches in chemoinformatics are numerous. Not only the error performance of a model resulting from the selected compounds is of importance, but also reliability, consistency, stability and robustness against small variations in the dataset…
Fecha:	2013-06-30
Recurso:	Computacional and structural biotechnology journal

Recurso libre

14.

Computational Tools for the Secondary Analysis of Metabolomics Experiments
Booth, Sean Cameron; Department of Biological Sciences University of Calgary - Weljie, Aalim; University of Pennsylvania - Turner, Raymond Joseph; University of Calgary

Formato:	info:eu-repo/semantics/article, info:eu-repo/semantics/publishedVersion, Peer-reviewed Article
Enlaces:	Metabolomics experiments have become commonplace in a wide variety of disciplines. By identifying and quantifying metabolites researchers can achieve a systems level understanding of metabolism. These studies produce vast swaths of data which are often only lightly interpreted due to…
Fecha:	2013-02-06
Recurso:	Computacional and structural biotechnology journal

Recurso libre

15.

A Two-stage Peak Alignment Algorithm for Two-Dimensional Gas Chromatography Time-of-Flight Mass Spectrometry-Based Metabolomics
Wang, Bing; Tongji University

Formato:	info:eu-repo/semantics/article, info:eu-repo/semantics/publishedVersion, Peer-reviewed Article
Enlaces:	Comprehensive two-dimensional gas chromatography coupled with time-of-flight mass spectrometry (GC×GC/TOF-MS) has been applied to metabolomics analyses recently. However, retention time shifts in the two-dimensional gas chromatography will introduce difficulty to compare compound profiles obtained from multiple samples. In this work,…
Fecha:	2013-06-19
Recurso:	Computacional and structural biotechnology journal

Recurso libre

16.

Biomarker signature identification in “omics” data with multi-class outcome
Lagani, Vincenzo; Institute of Computer Science, Foundation for Research and Technology – Hellas (FORTH) - Kortas, George; Department of Computer Science, University of Crete - Tsamardinos, Ioannis; Institute of Computer Science, Foundation for Research and Technology – Hellas (FORTH) Department of Computer Science, University of Crete

Formato:	info:eu-repo/semantics/article, info:eu-repo/semantics/publishedVersion,
Enlaces:	Biomarker signature identification in “omics” data is a complex challenge that requires specialized feature selection algorithms. The objective of these algorithms is to select the smallest set(s) of molecular quantities that are able to predict a given outcome (target) with…
Fecha:	2013-06-08
Recurso:	Computacional and structural biotechnology journal

Recurso libre

17.

Study of Uremic Toxin Fluxes Across Nanofabricated Hemodialysis Membranes Using Irreversible Thermodynamics
Hedayat, Assem; University of Saskatchewan - Peace, Rob - Elmoselhi, Hamdi; Saskatchewan Transplant Program, St. Paul’s Hospital, 1702, 20th Street West, Saskatoon, SK, Canada S7M 0Z9 - Shoker, Ahmed; Director, Saskatchewan Transplant Program, St. Paul’s Hospital, 1702, 20th Street West, Saskatoon, SK, Canada S7M 0Z9 Division of Nephrology, Department of Medicine, University of Saskatchewan, 103 Hospital Drive, Saskatoon, SK, Canada S7N 0W8

Formato:	info:eu-repo/semantics/article, info:eu-repo/semantics/publishedVersion,
Enlaces:	Introduction: The flux of uremic toxin middle molecules through currently used hemodialysis membranes is suboptimal, mainly because of the membranes’ pore architecture. Aim: Identifying the modifiable sieving parameters that can be improved by nanotechnology to enhance fluxes of uremic toxins…
Fecha:	2013-06-11
Recurso:	Computacional and structural biotechnology journal