The volume of literature on the morphology and physiology of the vasculature is enormous. The concepts of the structure and activity of the blood vessels have changed greatly in the post fifteen years with the availability of revolutionary tools such…

The bias in the development of biochemistry to which Baldwin (1940) drew attention in 1937 has not been remedied in the last two decades. Despite the tremendous advances in our knowledge of the biochemistry of mammals and unicellular organisms made…

A quarter of a century has elapsed since the first steroid hormone was isolated. Since then, there has been a profound and significant advance in our knowledge of the biogenesis of these steroid hormones and their ultimate fate in the…

The beginning of our knowledge of the enzyme lactic dehydrogenase, dates back to Otto Meyerhof's discovery (1) in 1919, that washed muscle preparations can oxidise lactic acid. The enzyme was obtained in soluble form by Stephenson (2) in 1928, from…

Miescher, who may be regarded as the founder of the knowledge of the chemistry of the cell nucleus, carried out his initial investigations on isolated pus nuclei obtained from discarded surgical bandages. He showed (1) that the nuclear material contained…

The study of glycolysis is a broad and extensive subject. The amount of published data dealing with glycolysis in different tissues and systems, as well as referring to special aspects of the process, are abundant and most of them of…

The beginning of our knowledge of the vitamin folic acid dates back to the discovery of Wills (1) in 1931 that the macrocytic anemia of pregnancy frequently observed in the tropics responded to oral administration of concentrated extracts of autolysed…

The peripheral circulation has long been an object of intense study. Besides its obvious medical importance, for example, in shock and hypertension, it is a fundamental factor in the integration of the various organs of the vertebrate body. A great…

A review of the literature on the physical and chemical properties of serum lipoproteins is given with a discussion on current knowledge of their biosynthesis and role in fat transport. Lipoprotein metabolism in the rat was studied by use of…

Although muscular dystrophy was first described over 100 years ago, little progress has been made towards the understanding of the basic defects responsible for this affliction. Recent clinical, biochemical, histochemical, and histological studies have added knowledge and increased our understanding…