| Título: | Effects of intramuscular injection of carnitylcholine on enzyme movements in rat tissues |
| Autores: | Pang, David C. |
| Fecha: | 1967. |
| Publicador: | McGill University - MCGILL |
| Fuente: |
 |
| Tipo: | Electronic Thesis or Dissertation |
| Tema: | Biochemistry. |
| Descripción: | Although muscular dystrophy was first described over 100 years ago, little progress has been made towards the understanding of the basic defects responsible for this affliction. Recent clinical, biochemical, histochemical, and histological studies have added knowledge and increased our understanding of this disease, but its fundamental nature is still unknown. Recent discovery of acetylcarnitylcholine in rat tissues has led us into investigating a hydrolytic product of it, namely, carnitylcholine. Injection of carnitylcholine into rat muscle caused enzyme movements from muscle to serum. This drug increased the activity of the pentose phosphate shunt in muscle and also caused an excess excretion of creatine and inorganic phosphate in the urine of experimental rats. These biochemical properties of carnitylcholine, its pharmacological actions, and its possible natural-occurrence, have led us to postulate that carnitylcholine, or some closely related substance, might be a causative factor in the etiology of Progressive Muscular Dystrophy. |
| Idioma: | en |
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