This research explores the metabolic role of the gut microbiota in the global
obesity crisis and rising threat of global warming. Enteric microbiota in the rumen emit
methane as a by-product of metabolite degradation. Experiments – primarily on mice –

In this thesis, we investigated a sequential decision making problem. We tested
different policies for online portfolio optimization: for a given number of assets and
a time horizon, the weights on assets are rebalanced at every time step according to

The purpose of this thesis was to simultaneously test a new theoretical model,
vicarious hypocrisy, which has been shown to produce changes in people’s
sunblock usage attitudes and behavior, and to apply this model to another
important health domain, dental…

Detecting and characterizing extrasolar planets has become a very relevant field in Astrophysics. There are several methods to achieve this, but by far the most difficult and potentially most rewarding approach is direct imaging of the planets. Coronagraphs can be…

This dissertation is a history of astronomy in three cultural locations in late Ottoman Egypt: the scholarly culture of Muslim ulama, the state institution of the Viceregal Observatory, and the Arabic press. Through an interwoven history of these cultures, the…

During the twentieth century, tobacco farmers in rural North Carolina quietly changed the relationship between the government and citizen in America . Flue-cured tobacco growers produced not only the finest cigarette leaf, but also new systems of marketing, regulating, and…

Protein domain prediction is a key step in characterizing protein structure, function, and evolution. However, the genome of Plasmodium falciparum, the causative agent of malignant malaria, remains poorly-annotated using standard approaches to domain prediction. We identified several general problems with…

Human cells are protected by cell-intrinsic mechanisms that specifically detect microbial pathogens and elicit innate immune response. Such activities are essential in restricting viral infections. Despite the extensive knowledge about cytoplasmic sensing processes, little is understood about the nuclear counterpart.…

Malaria and diarrhea are major causes of illness and death in Africa. These preventable diseases take the biggest toll on children, mostly due to lack of education and adequate resources in the home. The purpose of the reported research project…

The antimicrobial effects of copper have been well established and may prove to be an effective means of reducing nosocomial or hospital-acquired infections. However, discussions surrounding the antimicrobial properties of copper-containing surfaces rarely address the effect of such materials on…