Understanding the biological signals encoded in a genome is a key challenge of computational biology. These signals are encoded in the four-nucleotide alphabet of DNA and are responsible for all molecular processes in the cell. In particular, the genome contains…

This thesis explores how doctors and nurses use documents to share their knowledge within and across healthcare settings. In addressing this question I draw on a 15-month, multi-sited ethnographic study in several pediatric health care settings, following patients from primary…

The shift towards global networking brings with it many opportunities and challenges. In this paper, we discuss key technologies in achieving global semantic interoperability among heterogeneous information systems, including both traditional and web data sources. In particular, we focus on…

This paper investigates the potential for a carbon tax to induce R&D, and for the consequent induced technical change (ITC) to lower the macroeconomic cost of abating carbon emissions. ITC is modelled within a general equilibrium simulation of the U.S.…

by Peter L. Grant., Thesis (S.M.M.O.T.)--Massachusetts Institute of Technology, Sloan School of Management, Management of Technology Program, 2000., Includes bibliographical references (p. 105-108).

This thesis will explore the design and optimization of a peer-to-peer network application as a solution to complex content management problems. Currently, most content management systems are expensive, cumbersome and inflexible custom solutions that require knowledge workers to change their…

Knowledge of how groups of people interact is important in many disciplines, e.g. organizational behavior, social network analysis, knowledge management and ubiquitous computing. Existing studies of social network interactions have either been restricted to online communities, where unambiguous measurements about…

by Shawn W. Ritchie., Thesis (S.M.)--Massachusetts Institute of Technology, System Design and Management Program, 1999., Includes bibliographical references (leaves 80-81).

by Roberta M. Braum., Thesis (S.M.)--Massachusetts Institute of Technology, Sloan School of Management; and, (S.M.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1999., Includes bibliographical references (p. 57).

by Gloria G. Moncayo., Thesis (M.B.A.)--Massachusetts Institute of Technology, Sloan School of Management, 1999., Includes bibliographical references (leaves 87-88).