This thesis describes a framework for collecting, analyzing, and visualizing dynamic data, particularly data gathered through Web questionnaires. The framework addresses challenges such as promoting user participation, handling missing or invalid data, and streamlining the data interpretation process. Tools in…

The next generations of both biological engineering and computer engineering demand that control be exerted at the molecular level. Creating, characterizing and controlling synthetic biological systems may provide us with the ability to build cells that are capable of a…

The CancerFit computer program allows cancer researchers to analyze epidemiologic data describing the age-specific risk of cancer in terms of hypotheses about historical environmental risks, the heritability of cancer, the role of gender and the processes embedded in cancer formation.…

Java programs are deployed in a bytecode format that is executed by a Java virtual machine (JVM). JVM performance is determined by several major components: execution engine, garbage collector, and threading system. The static compilation and optimization approach, such as…

In designing compiler analyses and optimisations, the choice of intermediate representation (IR) is a crucial one. Static Single Assignment (SSA) form in particular is an IR with interesting properties, enabling certain analyses and optimisations to be more easily implemented while…

Side-effect analysis gives information about the set of locations that a statement may read or modify. This analysis can provide information useful in a compiler for performing aggressive optimizations. The impact of the use of side-effect analysis in compiler optimizations…

A fundamental problem in interprocedural program analyses is the need to represent and manipulate collections of large sets. Binary Decision Diagrams (BDDs) are a data structure widely used in model checking to compactly encode large state sets. In this dissertation,…

With the development of multi-processors, multi-threaded programs and programming languages have become more and more popular. This requires extending the scope of program analysis and compiler optimization from traditional, sequential programs to concurrent programs., Naumovich et al. proposed May Happen…

In the last decade, the video game industry has shown unparalleled growth, both in revenue and in development complexity. Modern video games are built using powerful game development tools. However, given their complexity and scope, these tools are ill-suited for…

AspectJ is a popular aspect-oriented extension to Java, providing powerful new features for the modularizing of crosscutting concerns, promising improved code quality. The runtime cost of these features, however, is currently not well understood, and is a concern limiting even…