| Título: | Formulation and Study of Some Controlled Release Tablets with Pentoxifylline Based on Hydroxypropylcellulose Matrix Obtained by Wet Granulation Method with PEG 6000 |
| Autores: |
Eleonora Mircia; University of Medicine and Pharmacy of Targu Mures Silvia Imre; University of Medicine and Pharmacy of Targu Mures Teodora Balaci; "Carol Davila" University of Medicine and Pharmacy, Bucharest Veronica Avrigeanu; University of Medicine and Pharmacy of Targu Mures Gabriel Hancu; University of Medicine and Pharmacy of Targu Mures |
| Fecha: | 2011-01-24 |
| Publicador: | BRAIN: Broad Research in Artificial Intelligence and Neuroscience |
| Fuente: |
 |
| Tipo: | |
| Tema: |
Pharmacology, Medicine pentoxifylline, hydrophilic matrix, hydroxypropylcellulose, controlled release, pharmaceutical forms 2000 Mathematics Subject Classification: 92C50, 97M60 |
| Descripción: | In this work three formulations of modified release tabletscontaining pentoxifylline 400 mg/tablet were obtained. Hydroxypropylcellulose (HPC) in di®erent ratios was used as hydrophilic matrix agent. The pentoxifylline inclusion in the matrix has been carried out by water granulation, using PEG 6000 as binder. Tablets were obtained with a single stationtablet machine (Korsch), using standard pressure, and obtaining tablets with 13 mm diameter, 800 mg weight and 400 mg pentoxifylline per tablet. The weight uniformity, friability, hardness, thickness and disintegration of tablets were determined according to the stipulations of the 2001 Supplement of the Romanian Pharmacopoeia Xth edition. The experimental formulations with 400 mg pentoxifylline/tablet were studied by comparing them to the industrial reference product, Trental 400 mg (Aventis Pharma) and in accordingto the stipulations of Romanian Pharmacopoeia Xth edition, USP 27 and European Pharmacopoeia 5th edition. Every determination was performed using 20 tablets. We followed the comparison between dissolution profiles of slow release tablets containing pentoxifylline based on hydrophilic matrix. The dissolution studies were performed using the method from USP 24, using the paddle apparatus, and water as medium of dissolution at 37+/-0,5 Celsius degrees, at a rotation speed of 50 rpm. The determination was performed by spectrofotometric as say in UV at 274 nm. It was noticeable that regarding the weight uniformity, friability, hardness, thickness and disintegration the proposed formulations are comparable with the industrial reference product (Trental, 400 mg) and are in agreement with the stipulations of the Romanian Pharmacopoeia Xth edition and European Pharmacopoeia 5th edition. The analysis of dissolution profiles showed that all formulations exhibit slow release. |
| Idioma: | Inglés |
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