| Título: | Three-component coupling of aldehydes, amines and alkynes catalyzed by oxidized copper nanoparticles on titania |
| Autores: |
Albaladejo Maricó, María José Alonso Valdés, Francisco Moglie, Yanina Yus Astiz, Miguel |
| Fecha: |
2012-05-28 2012-05-28 2012 2012-03-15 |
| Publicador: | RUA Docencia |
| Fuente: |
 |
| Tipo: | info:eu-repo/semantics/article |
| Tema: |
Multicomponent reactions Nanoparticles Copper Alkynes Aldehydes Amines Química Orgánica |
| Descripción: |
Copper nanoparticles (mainly as Cu2O) on titania have been shown to catalyze the multicomponent synthesis of propargylamines from aldehydes, amines, and alkynes (A3 coupling) effectively at 70 °C under solvent-free conditions. Both aromatic and aliphatic aldehydes and alkynes have been combined with secondary amines to provide a wide range of propargylamines in moderate to excellent yields. Two examples of ketone/amine/alkyne (KA2) coupling are also included. The catalyst is easy to prepare, reusable at a low copper loading (0.5 mol-%), and exhibits higher catalytic activity than some commercially available copper sources. Some mechanistic aspects of the reaction have also been examined, which have unveiled the participation of copper(I) acetylides in a heterogeneous process. This work was generously supported by the Spanish Ministerio de Ciencia e Innovación (MICINN) (grant numbers CTQ2007-65218, CTQ2011-24151), Consolider Ingenio (grant number 2010-CSD2007-00006), the Generalitat Valenciana (grant number PROMETEO/2009/039), and Fondos Europeos para el Desarrollo Regional (FEDER). Y. M. and M. J .A. acknowledge the ISO of the Universidad de Alicante for a grant. |
| Idioma: | Inglés |
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