| Título: | Pre-osteoblast response to three-dimensional titanium scaffolds for bone regeneration applications |
| Autores: | St-Pierre, Jean-Philippe |
| Fecha: | 2004 |
| Publicador: | McGill University - MCGILL |
| Fuente: |
 |
| Tipo: | Electronic Thesis or Dissertation |
| Tema: | Engineering, Biomedical. |
| Descripción: | Porous metals are often used in orthopaedic load-bearing applications because they promote and direct bone ingrowth while maintaining their mechanical integrity for long periods in physiological environments. However, the influence of microstructural parameters of three-dimensional metallic scaffolds on osteogenic cell response must be studied to improve their design. This study aims to study the biocompatibility and osteoconductivity of novel titanium foams with three pore sizes in vitro and to gain knowledge on the mechanisms by which bone is formed within three-dimensional structures. This is achieved through studies of the cell viability of macrophages and adhesion kinetics, proliferation, differentiation, and mineralization of the extracellular matrix by MCT3-E1 mouse pre-osteoblasts. Results indicate that porous titanium promotes the generation of mineralized extracellular matrix by differentiating pre-osteoblasts and stress the importance of controlling the pore size to allow the impregnation of the structure by tissue. |
| Idioma: | en |
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