Título: Evaluation and implementation of an automated blood sampling system for positron emission tomographic studies
Autores: Vafaee, Manouchehr S.
Fecha: 1993
Publicador: McGill University - MCGILL
Fuente:
Tipo: Electronic Thesis or Dissertation
Tema: Engineering, Biomedical.
Health Sciences, Radiology.
Biophysics, Medical.
Descripción: Quantification of physiological functions with positron emission tomography requires knowledge of the arterial radioactivity concentration. Automated blood sampling systems increase the accuracy of this measurement, particularly for short-lived tracers such as oxygen-15, by reducing the sampling interval to a fraction of a second. They, however, require correction for tracer delay between the arterial puncture site and the external radiation detector (external delay), and for the tracer bolus distortion in the sampling catheter (external dispersion).
We have evaluated and implemented the "Scanditronix" automated blood sampling system and measured its external delay and dispersion. PET studies of cerebral blood flow and oxygen metabolism using simultaneous manual and automated blood sampling were analyzed and compared. We show that the results obtained with automated blood sampling are more reliable than those based on manual sampling. We also present suggestions to further improve the reliability of quantitative PET studies based on automated blood sampling.
Idioma: en