Título: An examination of the proportionality of hazards in epidemiology /
Autores: Scott, Susan C. (Susan Catherine)
Fecha: 1992
Publicador: McGill University - MCGILL
Fuente:
Tipo: Electronic Thesis or Dissertation
Tema: Biology, Biostatistics.
Descripción: Additive and multiplicative statistical models in epidemiology invoke different assumptions regarding exposure-outcome relationships. While either may seem to provide an adequate fit in small data sets, a comparative parameter based on the correct set of assumptions will be more stable when applied in other contexts. Important implications of model selection and the scant literature on theoretical reasoning are presented. Given a lack of biological knowledge, a body of corroborative empirical knowledge would be helpful in choosing between statistical models. Traditionally, the fit of a multiplicative model is evaluated by a $ chi sp2$ test of homogeneity. However, this is a test rather than a measure and is sample-size dependent. In this thesis, the development of a new measure of heterogeneity of rate ratios, phi prime, is presented and applied to stomach cancer registry data. Results suggest homogeneity when comparing regions within countries, but some heterogeneity between continents.
Idioma: en