| Título: | Cancer cells induced to express mesenchymal phenotype release exosome-like extracellular vesicles carrying tissue factor |
| Autores: |
Rak, Janusz Garnier, Delphine Magnus, Nathalie Lee, Tae H. Bentley, Victoria Meehan, Brian Milsom, Chloe Montermini, Laura Kislinger, Thomas |
| Fecha: | 2012 |
| Publicador: | McGill University - MCGILL |
| Fuente: |
 |
| Tipo: | Postprint |
| Tema: | Cancer Research |
| Descripción: | Aggressive epithelial cancer cells frequentlyadopt mesenchymal characteristics and exhibitaberrant interactions with their surroundings,including the vasculature. Whether therelease/uptake of extracellular vesicles (EVs)plays a role during these processes has not beenstudied. EVs are heterogeneous membranestructures that originate either at the surface(microparticles), or within (exosomes) activatedor transformed cells, and are involved inintercellular trafficking of bioactive molecules.Here we show that epithelial cancer cells (A431,DLD-1) adopt mesenchymal features (EMT-likestate) upon activation of epidermal growthfactor receptor (EGFR) coupled with blockadeof E-cadherin. This treatment leads to acoordinated loss of EGFR and tissue factor (TF)from the plasma membrane and coincides witha surge in emission of small, exosome-like EVscontaining both receptors. TF (but not EGFR)is selectively upregulated in EVs produced bymesenchymal-like cancer cells, and can betransferred to cultured endothelial cellsrendering them highly procoagulant. Wepostulate that EMT-like changes may altercancer cell interactions with the vascularsystems through altered vesiculation and TFshedding. |
| Idioma: | eng |
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