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Título: Hormonal effects on fat deposition in the liver.
Autores: Berman, Doreen.
Fecha: 1946.
Publicador: McGill University - MCGILL
Fuente:
Tipo: Electronic Thesis or Dissertation
Tema: Hormones.
Liver.
Descripción: Stimuli which cause the accumulation of increased amounts of fat in the liver have interested both the clinician and the biochemist. To the former, they are of import, not only because fatty infiltration of the liver is found as a frequent pathological finding associated with various diseases, but also because this change has been shown to result in an impairment of hepatic function (129,380) and, if severe, to terminate in cirrhosis (79,83, 84,110,112). They are of interest to the latter as aids in the elucidation of fat metabolism, and therefore, indirectly, of other phases of metabolism. There is no doubt that the liver plays a highly important role in the assimilation and catabolism of lipid substances. Thus, the study of factors influencing liver fat have yielded particularly useful information as to the reactions involved. It is well known that several of the endocrine glands exercise pronounced, though not yet fully understood, effects upon carbohydrate and protein metabolism. Their influence on fat metabolism has not received such wide recognition. The first purpose of this thesis is to attempt to amass and correlate what is known of the endocrine factors influencing the deposition of hepatic fat. A complete understanding of factors affecting liver fat necessarily involves a knowledge, not only of the effect of these factors on fat metabolism itself, but also of their effect on carbohydrate and protein metabolism. To cover the whole of this field would not be feasible within the limits of a single thesis. The discussion has, therefore, been restricted to a consideration of factors that directly result in an alteration in the amount of hepatic fat [...]
Idioma: en