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Título: Entry of radio-phosphorus into the bones of the newborn rat.
Autores: Robichon, Jacques.
Fecha: 1950
Publicador: McGill University - MCGILL
Fuente:
Tipo: Electronic Thesis or Dissertation
Tema: Experimental Surgery.
Descripción: It is known that the bone consists of crystals of a Calcium phosphate complex held together in a matrix derived from connective tissue. The phosphate salts are responsible for the firmness and resistance which are two of the main characteristics of bone. The problem of bone formation has been approached in two ways; First, histologically by the comparison of bones from animals of various ages; Secondly, by chemical estimation of bone salts and more recently phosphatase. In spite of the large amount of knowledge accumulated on the subject, many points are still obscure. Indeed, our knowledge of bone formation has hardly improved since the end of the last century. However, the availability of P^32 has offered a new method of approach, which so far has only been used by biochemists (Hevesy in Denmark; Hodge and collaborators in Rochester.). Their work led them to the conclusion that bone contains two different types of phosphates, a labile fraction which is in continuous exchange with the phosphate of the blood and a stable fraction which remains fixed in the skeleton. The relation of these findings to the problem of ossification remains, however, quite obscure.[...]
Idioma: en