| Título: | Randomized Clinical Trial: Efficacy of a New Synbiotic in Adults with Metabolic Syndrome |
| Autores: |
Kushugulova, Almagul; Center for Life Sciences, Nazarbaev University, Astana Benberin, Valerii; Medical Center of President's Affairs Administration of Republic of Kazakhstan, Astana Karabayeva, Raushan; Medical Center of President's Affairs Administration of Republic of Kazakhstan, Astana Saduakhasova, Saule; Center for Life Sciences, Nazarbaev University, Astana Kozhakhmetov, Samat; Center for Life Sciences, Nazarbaev University, Astana Shakhabayeva, Gulnara; Center for Life Sciences, Nazarbaev University, Astana Tynybayeva, Indira; Center for Life Sciences, Nazarbaev University, Astana Nurgozhin, Talgat; Center for Life Sciences, Nazarbaev University, Astana Zhumadilov, Zhaxybay; Center for Life Sciences, Nazarbaev University, Astana |
| Fecha: | 2014-01-24 |
| Publicador: | Central Asian Journal of Global Hearth |
| Fuente: |
 |
| Tipo: | |
| Tema: | No aplica |
| Descripción: | Introduction: Metabolic syndrome is a lifestyle disease and is a frequent problem among the adult population. Human gut microbiota plays a key role in the development of metabolic syndrome. Recently, the gut microbiota has emerged as an important contributor to the development of obesity and metabolic disorders through its interactions with environmental (e.g. diet) and genetic factors. The aim of this study was to research the effects of synbiotic on the gut microbiota and host metabolism. Methods: We conducted a double-blind, randomized, placebo-controlled trial. Our sample included 180 adults (ages 30-89) with symptoms of metabolic syndrome, who were allocated to either placebo or synbiotic group. The main inclusion criteria were: blood pressure of around 130/90 mmHg; raised fasting plasma glucose (FPG) >100 mg/dL (5.6 mmol/L), previous diagnosis of type 2 diabetes, dyslipidemia triglycerides (TG) of 1.70 mmol/L, a high-density lipoprotein cholesterol (HDL-C) of 0.90 mmol/L in males and 1.0 mmol/L in females, and central obesity with a waist/hip ratio > 0.90 in males or > 0.85 in females or a body mass index > 30 kg/m2. Results: We enrolled 90 adults in the placebo group and 90 in the synbiotic group. The two groups had similar demographic and clinical characteristics. Consent was signed by all patients. All patients underwent clinical and laboratory evaluation, including complete blood tests, glucose test, glycosylated hemoglobin, total cholesterol and triglycerides, cholesterol, LDL, HDL plasma, immunogram, and coprogram. All patients were interviewed with a questionnaire that included 200 questions related to diet, lifestyle, and health. Synbiotic were used by patients in a dose of 200 grams twice a day. The duration of applying of the synbiotic was 90 days. To study the composition of the intestinal microbiota, stool samples were collected before and after applying the synbiotic. The microbial composition will be determined by analyzing the locus of 16S rDNA. Conclusion: This ongoing study is currently undergoing microbial composition analysis in order to establish the efficacy of the new synbiotic in adults with metabolic syndrome. |
| Idioma: | Inglés |
1 The Central Asian Journal of Global Health: A Supercourse Journal por Linkov, Faina; University of Pittsburgh,LaPorte, Ronald; University of Pittsburgh | 6 The HUPO Human Proteome Project (HPP), a Global Health Research Collaboration por Omenn, Gilbert S.; University of Michigan |
2 New directions in building a scientific social network: Experiences in the Supercourse project and application to Central Asia por Hennon, Meredith; University of Pittsburgh,LaPorte, Ronald E.; University of Pittsburgh,Shubnikov, Eugene; Institute of Internal Medicine, Novosibirsk, Russia,Linkov, Faina; University of Pittsburgh | 7 Keeping Up with the Times por Burambayeva, Valentina |
3 Modernization and growth in Kazakhstan por Sharman, Almaz; Nazarbayev University | 8 Public Health Challenges and Priorities for Kazakhstan por Aringazina, Altyn; Kazakhstan School of Public Health, Almaty, Republic of Kazakhstan,Gulis, Gabriel; University of Southern Denmark, Esbjerg, Denmark,Allegrante, John P.; Columbia University |
4 Missing Millions and Measuring Progress towards the Millenium Development Goals with a focus on Central Asian States por Carr-Hill, Roy; Centre for Health Economics,
University of York
YORK, YO10 5DD
UK | 9 Effects of Amyloid Beta Peptide on Neurovascular Cells por Askarova, Sholpan; Center for Life Sciences, Nazarbaev University,Tsoy, Andrey; Department of Biodiversity and Bioresources
71 Al-Farabi av. Biological Faculty Building
Al-Farabi Kazakh National University,Shalakhmetova, Tamara; Al-Farabi Kazakh National University, Biology Faculty, Almaty,Lee, James C-M; Department of Biological Engineering
240 Agricultural Engineering Building
University of Missouri - Columbia |
5 The Case of NRENs in Central Asia por Janz, Robert Franciscus; Centre for Information Technology,
University of Groningen,Kutanov, Askar; Academician, National Academy of Sciences, Kyrgyz Republic | 10 Is the Supercourse useful for Latin America? por Padilla-Raygoza, Nicolas; University of Guanajuato,Linkov, Faina; Division of Cancer Prevention and Population Science, University of Pittsburgh Cancer Institute,Shubnikov, Eugene; Institute of Internal Medicine, Novosibirsk, Russian Federation,LaPorte, Ronald E.; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh Cancer Institute,Diaz-Guerrero, Rosalina; Departrment of Nursing and Obstetrics, Division of Health Sciences and Engineering, Campus Celaya Salvatierra, University of Guanajuato |