| Título: | Effects of Amyloid Beta Peptide on Neurovascular Cells |
| Autores: |
Askarova, Sholpan; Center for Life Sciences, Nazarbaev University Tsoy, Andrey; Department of Biodiversity and Bioresources 71 Al-Farabi av. Biological Faculty Building Al-Farabi Kazakh National University Shalakhmetova, Tamara; Al-Farabi Kazakh National University, Biology Faculty, Almaty Lee, James C-M; Department of Biological Engineering 240 Agricultural Engineering Building University of Missouri - Columbia |
| Fecha: | 2012-08-29 |
| Publicador: | Central Asian Journal of Global Hearth |
| Fuente: |
 |
| Tipo: | |
| Tema: | No aplica |
| Descripción: | Alzheimer’s disease (AD) is a chronic neurodegenerative disorder, which is characterized by the accumulation of amyloid plaques and neurofibrillary tangles in specific regions of the brain, accompanied by impairment of the neurons, and progressive deterioration of cognition and memory of affected individuals. Although the cause and progression of AD are still not well understood, the amyloid hypothesis is dominant and widely accepted. According to this hypothesis, an increased deposition of amyloid-β peptide (Aβ) in the brain is the main cause of the AD’s onset and progression. There is increasing body of evidence that blood-brain barrier (BBB) dysfunction plays an important role in the development of AD, and may even precede neuron degeneration in AD brain. In the early stage of AD, microvasculature deficiencies, inflammatory reactions, surrounding the cerebral vasculature and endothelial dysfunctions are commonly observed. Continuous neurovascular degeneration and accumulation of Aβ on blood vessels resulting in cerebral amyloid angiopathy is associated with further progression of the disease and cognitive decline. However, little is known about molecular mechanisms that underlie Aβ induced damage of neurovascular cells. In this regards, this review is aimed to address how Aβ impacts the cerebral endothelium. Understanding the cellular pathways triggered by Aβ leading to alterations in cerebral endothelial cells structure and functions would provide insights into the mechanism of BBB dysfunction and inflammatory processes in Alzheimer’s, and may offer new approaches for prevention and treatment strategies for AD. |
| Idioma: | Inglés |
1 The Central Asian Journal of Global Health: A Supercourse Journal por Linkov, Faina; University of Pittsburgh,LaPorte, Ronald; University of Pittsburgh | 6 The HUPO Human Proteome Project (HPP), a Global Health Research Collaboration por Omenn, Gilbert S.; University of Michigan |
2 New directions in building a scientific social network: Experiences in the Supercourse project and application to Central Asia por Hennon, Meredith; University of Pittsburgh,LaPorte, Ronald E.; University of Pittsburgh,Shubnikov, Eugene; Institute of Internal Medicine, Novosibirsk, Russia,Linkov, Faina; University of Pittsburgh | 7 Keeping Up with the Times por Burambayeva, Valentina |
3 Modernization and growth in Kazakhstan por Sharman, Almaz; Nazarbayev University | 8 Public Health Challenges and Priorities for Kazakhstan por Aringazina, Altyn; Kazakhstan School of Public Health, Almaty, Republic of Kazakhstan,Gulis, Gabriel; University of Southern Denmark, Esbjerg, Denmark,Allegrante, John P.; Columbia University |
4 Missing Millions and Measuring Progress towards the Millenium Development Goals with a focus on Central Asian States por Carr-Hill, Roy; Centre for Health Economics,
University of York
YORK, YO10 5DD
UK | 9 Is the Supercourse useful for Latin America? por Padilla-Raygoza, Nicolas; University of Guanajuato,Linkov, Faina; Division of Cancer Prevention and Population Science, University of Pittsburgh Cancer Institute,Shubnikov, Eugene; Institute of Internal Medicine, Novosibirsk, Russian Federation,LaPorte, Ronald E.; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh Cancer Institute,Diaz-Guerrero, Rosalina; Departrment of Nursing and Obstetrics, Division of Health Sciences and Engineering, Campus Celaya Salvatierra, University of Guanajuato |
5 The Case of NRENs in Central Asia por Janz, Robert Franciscus; Centre for Information Technology,
University of Groningen,Kutanov, Askar; Academician, National Academy of Sciences, Kyrgyz Republic | 10 The Central Asian Supercourse to Increase Scientific Productivity por Linkov, Faina; Magee-Women's Research Institute, University of Pittsburgh,Guzman, Robert; University of Pittsburgh,Soisson, Sean; Gynecologic Oncology, Magee-Women's Hospital,Freese, Kyle E.; Magee-Women's Research Institute, University of Pittsburgh,Sheikh, Aamir H.; University of Pittsburgh,Shubnikov, Eugene; Research Scientist, Institute of Internal Medicine, Novosibirsk, Russia,LaPorte, Ronald E.; Graduate School of Public Health, Department of Epidemiology, University of Pittsburgh |