| Título: | Frequency of NAT2 and GSTP1 polymorphisms in the Kazakh population |
| Autores: |
Iskakova, Aisha; National Center for Biotechnology, Astana Romanova, Aliya; National Center for Biotechnology, Astana Zholdybayeva, Elena; National Center for Biotechnology, Astana Ramanculov, Erlan; Nazarbayev University, Astana Momynaliev, Kuvat; National Center for Biotechnology, Astana |
| Fecha: | 2014-01-24 |
| Publicador: | Central Asian Journal of Global Hearth |
| Fuente: |
 |
| Tipo: | |
| Tema: | No aplica |
| Descripción: | Introduction: Phase II xenobiotic biotransformation enzymes perform detoxification of hydrophilic and often toxic Phase I products by glutathionetransferase (GST), UDP-glucuronosyltransferase (UDF), N-acetyltransferase (NAT) families and other enzymes. GST protein family metabolizes a large number of electrophilic xenobiotics, including drugs, by conjugating them with glutathione. Arylamine-N-acetyltransferase (NAT) catalyzes the acetylation of the aromatic and heterocyclic amines. Materials and methods: The current study has assessed the frequencies of NAT2 and GSTP1 genes polymorphisms in 326 healthy individuals from different regions of Kazakhstan by using Real-Time PCR and direct sequencing methods. Results: Allele frequencies were derived for NAT2*5 (0.54) and GSTP1 (0.27). GSTP1 alleles were in Hardy – Weinberg equilibrium (p > 0.05), while NAT2*5 (p = 0.00) were not. The population differences between North, Northeast and South Kazakhstan regions were determined. Statistically significant differences in the frequency of genotypes were not found. Conclusion: Allelic polymorphisms of NAT2*5 and GSTP1 genes vary widely in different populations. Kazakh population was significantly different from Asian, Caucasoid, African-American and Hispanic ones by NAT2*5 and GSTP1 genes. Allelic variants of the NAT2*5 were detected with a low frequency in Asian populations. Allelic frequency in other world populations varies from 30 to 50%. The differences between Kazakh (0.54) and the world population were statistically significant (p < 0.05). The frequency of GSTP1 (rs1695) in the African American population is 42%. The frequency of GSTP1 in Asian populations varies from 11% to 23%, in Caucasoid populations it is about 30%. The differences between Kazakh population (0.27) and other populations selected from the literature were statistically significant (p < 0.05). The study of mutations in GSTP1 and NAT2 genes is necessary to assess the risk of the development of various diseases, such as cancer. Information on allelic polymorphisms also might be useful for personalized drug prescription for such drugs as cyclophosphamide, cisplatin, methotrexate, isoniazid, pyrazinamide, and rifampin. |
| Idioma: | Inglés |
1 The Central Asian Journal of Global Health: A Supercourse Journal por Linkov, Faina; University of Pittsburgh,LaPorte, Ronald; University of Pittsburgh | 6 The HUPO Human Proteome Project (HPP), a Global Health Research Collaboration por Omenn, Gilbert S.; University of Michigan |
2 New directions in building a scientific social network: Experiences in the Supercourse project and application to Central Asia por Hennon, Meredith; University of Pittsburgh,LaPorte, Ronald E.; University of Pittsburgh,Shubnikov, Eugene; Institute of Internal Medicine, Novosibirsk, Russia,Linkov, Faina; University of Pittsburgh | 7 Keeping Up with the Times por Burambayeva, Valentina |
3 Modernization and growth in Kazakhstan por Sharman, Almaz; Nazarbayev University | 8 Public Health Challenges and Priorities for Kazakhstan por Aringazina, Altyn; Kazakhstan School of Public Health, Almaty, Republic of Kazakhstan,Gulis, Gabriel; University of Southern Denmark, Esbjerg, Denmark,Allegrante, John P.; Columbia University |
4 Missing Millions and Measuring Progress towards the Millenium Development Goals with a focus on Central Asian States por Carr-Hill, Roy; Centre for Health Economics,
University of York
YORK, YO10 5DD
UK | 9 Effects of Amyloid Beta Peptide on Neurovascular Cells por Askarova, Sholpan; Center for Life Sciences, Nazarbaev University,Tsoy, Andrey; Department of Biodiversity and Bioresources
71 Al-Farabi av. Biological Faculty Building
Al-Farabi Kazakh National University,Shalakhmetova, Tamara; Al-Farabi Kazakh National University, Biology Faculty, Almaty,Lee, James C-M; Department of Biological Engineering
240 Agricultural Engineering Building
University of Missouri - Columbia |
5 The Case of NRENs in Central Asia por Janz, Robert Franciscus; Centre for Information Technology,
University of Groningen,Kutanov, Askar; Academician, National Academy of Sciences, Kyrgyz Republic | 10 Is the Supercourse useful for Latin America? por Padilla-Raygoza, Nicolas; University of Guanajuato,Linkov, Faina; Division of Cancer Prevention and Population Science, University of Pittsburgh Cancer Institute,Shubnikov, Eugene; Institute of Internal Medicine, Novosibirsk, Russian Federation,LaPorte, Ronald E.; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh Cancer Institute,Diaz-Guerrero, Rosalina; Departrment of Nursing and Obstetrics, Division of Health Sciences and Engineering, Campus Celaya Salvatierra, University of Guanajuato |