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Título: La réactivité du cortisol salivaire de sujets souffrant de dépression majeure exposés à des stimuli émotifs et neutres /
Autores: Roy, Mario.
Fecha: 2002
Publicador: McGill University
Fuente: Ver documento
Tipo: Electronic Thesis or Dissertation
Tema: Biology, Neuroscience.
Descripción: The goal of the present study was to measure the reactivity of the salivary cortisol in depressed patients and controls exposed to emotional and neutral memory tasks.
We recruited 21 depressed patients, 9 in an active phase of depression, 12 in remission and 17 controls. The 3 groups were similar. The protocol consisted of a task to assess explicit memory in two separate conditions: neutral and emotional words to learn consciously on two separate days. During both assessments, we took salivary samples each 10 minutes to assess the concentration of free cortisol before, during and after the memory task.
A repeated analysis of variance was performed on the results of the memory task in two conditions for the 3 groups. An interaction was found between memory performance, conditions and the group [F (4, 64) = 3.053; p = 0.023]. Depressed subjects recalled less words than controls in the neutral condition at the tree different recall periods. The performance of the 3 groups were similar in term of the number of emotional words recalled.
An analysis of variance was performed with the repeated measures of cortisol. We found an interaction between the group and the condition [F(1,36) = 5.542; p = 0.024]. We observed a cortisol reactivity among depressed subjects after the memory task in the neutral condition. The reactivity in the emotional condition didn't show such variability in this group.
In conclusion, we observed a mood congruency effect in the memory task. Interestingly, the performance was similar for the 3 groups in the emotional condition suggesting that depressed subjects have a memory deficit only with irrelevant information according to the self schemata. The same rational can be used to explain the cortisol reactivity. Incongruent information according to the self schemata of depressed subjects is associated to a rise of the cortisol level.
Idioma: fr