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Título: Decodage de l'exposition professionnelle par l'analyse de particules extraites du parenchyme pulmonaire
Autores: Dufresne, André.
Fecha: 1990
Publicador: McGill University
Fuente: Ver documento
Tipo: Electronic Thesis or Dissertation
Tema: Health Sciences, Occupational Health and Safety.
Descripción: Occupational histories collected during interviews in an epidemiological study and then expressed as types and levels of occupational exposure have been compared to the results acquired in a physico-chemical analysis of the particles extracted from pulmonary parenchyma of forty-two subjects with different types of cancer. The original scenario was for a group of workers, ten exposed mainly to asbestos fibers, ten to silica, ten to welding fumes, six smokers, and six nonsmokers not exposed to the target contaminants. Fragments of tissue that had been formolated or covered in paraffin were used after having been standardized by two pathologists. The preparation and analytical protocols were validated so that a representative number of particles could be counted and "reasonably" characterized from their morphology and their chemical composition by transmission electron microscopy and laser microprobe mass analyser.
A Kappa test revealed that there was a limited correlation at the 5% level of confidence between the work history history and physico-chemical estimators for the group of subjects exposed to asbestos fiber (k = 0.475, p = 0.001), a 10% level for the group with silica exposure (k = 0.213, p = 0.089) and at a 5% level in the unexposed nonsmoker group (k = 0.417, p = 0.003). The average pulmonary dust burden of the log-normalized values for certain minerals that were extracted from subjects belonging to certain groups of interest were statistically different.
Idioma: fr