| Título: | High serum C1q-binding adiponectin levels in male patients with acute coronary syndrome |
| Autores: |
Kishida, Ken Nakagawa, Yasuhiko Kobayashi, Hironori Mazaki, Toru Yokoi, Hiroyoshi Yanagi, Koji Funahashi, Tohru Shimomura, Iichiro |
| Fecha: | 2014-01-09 |
| Publicador: | BioMed Central Ltd. |
| Fuente: |
Ver documento |
| Tipo: | Original investigation |
| Tema: | Adiponectin, C1q, C1q-binding adiponectin, Acute coronary syndrome |
| Descripción: | Abstract Background The complement system is part of the immune system in acute coronary syndrome (ACS). Adiponectin has anti-atherogenic and anti-inflammatory properties. Adiponectin and C1q form a protein complex in blood, and serum C1q binding adiponectin (C1q-APN) can be measured. We investigated the comparative evaluation of serum C1q-APN levels in males with ACS, stable angina pectoris (SAP) versus controls. Methods The study subjects were 138 Japanese patients who underwent diagnostic coronary angiography. Blood total adiponectin (Total-APN), C1q-APN and C1q were measured by enzyme-linked immunosorbent assays. Patients were divided into three groups according to the clinical condition: ACS (n = 78), SAP (n = 41) or normal coronary (NC, n = 19) groups. Results Serum C1q levels were significantly higher in the ACS group (54.9±1.2 μg/mL) than in the NC group (48.0±2.5 μg/mL). Although serum Total-APN levels were significantly lower in the SAP and ACS groups, compared with the NC group (7.0±0.5, 7.2±0.3, 10.6±2.0 μg/mL, respectively), serum C1q-APN levels were significantly higher in the ACS group than in the NC and SAP groups (112.1±4.1, 66.3±4.4, 65.7±2.9 units/mL, respectively). Conclusions Patients with ACS had higher serum C1q-APN levels. Trial Registration UMIN000002997 |
| Idioma: | Inglés |