| Título: | Plasma 25-hydroxyvitamin D3 is associated with decreased risk of postmenopausal breast cancer in whites: a nested case–control study in the multiethnic cohort study |
| Autores: |
Kim, Yeonju Franke, Adrian A Shvetsov, Yurii B Wilkens, Lynne R Cooney, Robert V Lurie, Galina Maskarinec, Gertraud Hernandez, Brenda Y Le Marchand, Loïc Henderson, Brian E Kolonel, Laurence N Goodman, Marc T |
| Fecha: | 2014-01-17 |
| Publicador: | BioMed Central Ltd. |
| Fuente: |
Ver documento |
| Tipo: | Research article |
| Tema: | Breast cancer, 25-Hydroxyvitamin D3, 25-Hydroxyvitamin D2, Ethnic groups, Nested case–control study |
| Descripción: | Abstract Background Higher sunlight exposure is correlated with lower incidence of breast cancer in ecological studies, but findings from prospective studies regarding the association of circulating levels of vitamin D with the risk of breast cancer have been null. The objective of this study was to examine the relation between plasma levels of vitamin D and the risk of postmenopausal breast cancer. Methods We conducted a nested case–control study within the Multiethnic Cohort Study of five race/ethnic groups (white, African-American, Native Hawaiian, Japanese, and Latino) from Hawaii and Los Angeles between 2001 and 2006. Pre-diagnostic plasma levels of 25-hydroxyvitamin D2 [25(OH)D 2 ], 25-hydroxyvitamin D3 [25(OH)D 3 ] and 25(OH)D (sum of 25(OH)D 2 and 25(OH)D 3 ) were examined among 707 postmenopausal breast cancer cases and matched controls. Results Using conditional logistic regression models, 20 ng/mL increases of plasma 25(OH)D 3 (odds ratio (OR) 0.28; 95% confidence interval (CI) 0.14-0.56) and 25(OH)D (OR 0.43; 95% CI 0.23-0.80) were inversely associated with breast cancer risk among white women, but not among women in other race/ethnic groups. Using two-segmented, piecewise-linear logistic regression models, the change-points of the ORs, either for 25(OH)D 3 or for 25(OH)D, were detected as 20 ng/mL among whites. Conclusions Circulating 25(OH)D 3 and 25(OH)D were associated with a reduced risk of postmenopausal breast cancer among whites, but not in other ethnic groups, who reside in low latitude regions. |
| Idioma: | Inglés |