| Título: | Pattern formation in the mammalian striatum: the development of the thalamostriatal projection in the rodent |
| Autores: | Srivastava, Vinit. |
| Fecha: | 1999 |
| Publicador: | McGill University - MCGILL |
| Fuente: |
 |
| Tipo: | Electronic Thesis or Dissertation |
| Tema: | Biology, Neuroscience. |
| Descripción: | Excitatory amino acids (EAAs) may play a role in sculpting mosaic patterns within the brain. Determining the role of EAA projection systems in sculpting the chemically heterogeneous striatal patch-matrix compartments requires knowledge concerning the spatiotemporal development of afferent EAA systems. EAA systems that afferent the striatum include amongst others, the thalamostriatal projection. The lipophilic tracer. DiI, is used for in vitro assessment of the growth of the thalamostriatal projection in prenatal rats whereas in a series of in vivo postnatal tract-tracing experiments, stereotactic injections of the tracer biocytin are made into the parafascicular (Pf) thalamic nucleus. This thesis has demonstrated that there are sparse thalamostriatal afferents detected at embryonic day 19 and significant fiber density by postnatal day 0. The projection afferents predominantly innervate the matrix as early as postnatal day 1. Specific tropic mechanisms must therefore account for the final pattern of thalamic afferents to the striatum. |
| Idioma: | en |
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